FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\trxZ32
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General Information
Symbol
Dmel\trxZ32
Species
D. melanogaster
Name
FlyBase ID
FBal0032931
Feature type
allele
Associated gene
Dmel\trx
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

heat sensitive hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

heat sensitive hypomorphic allele - genetic evidence

(Breen, 1999)
Mutagen
ethyl methanesulfonate
(Mortin et al., 1992)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygote adults show no transformation phenotype. Hemizygotes are viable at 22oC. Homozygotes are larval lethal. trxZ32/Df(3R)red-P52 hemizygotes show phenotypes that suggest decreased Scr function (transformation of T1 structures to a T2 identity), decreased Ubx function (transformation of T3 to T2), decreased abd-A function (transformation of A2-A7 to A1) and decreased Abd-B function (transformation of posterior abdominal segments to more anterior abdominal identities). Scr group transformations include the development of mesothoracic tibial preapical bristles or mesothoracic tibial apical bristles on the prothoracic tibia, reduced numbers of sex comb teeth (in males), development of sternopleural bristles on the T1 segment. Ubx group transformations include the development of T3 sternopleural bristles, mesothoracic tibial preapical bristles on the metathoracic tibia. Abd-B group transformations include the pigmentation of abdominal tergites 5 to 6 in males, and enlargement of abdominal tergite 7.

      (Breen, 1999)

      Loss of trx in enF4 flies causes female sterility.

      (Breen et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      trxM17

      (Breen, 1999)
      Partially complements

      trx6.1

      (Breen, 1999)

      trx7.1

      (Breen, 1999)

      trxJY16

      (Breen, 1999)

      trxJY25

      (Breen, 1999)

      trxE3

      (Breen, 1999)

      trxD

      (Breen, 1999)

      trx1

      (Breen, 1999)

      trxZ44

      (Breen, 1999)

      trxZ16

      (Breen, 1999)

      trxZ15

      (Breen, 1999)

      trxZ11

      (Breen, 1999)

      trxM14

      (Breen, 1999)

      trxM18

      (Breen, 1999)

      trxB11

      (Breen, 1999)

      trxA7

      (Breen, 1999)
      Comments

      Partial complementation between hypomorphs produced phenotypes that were weaker than either of the hemizygous or homozygous phenotypes, either rescuing lethality or producing a weaker homeotic transformation phenotype. Transformations range from an average of 0.80 to 4.19 transformations/fly (males were scored for a possible 29 transformations, females were scored for a possible 26 transformations) in different allelic combinations.

      (Breen, 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The following alleles form a series of progressively increasing penetrance and expressivity of phenotype when in transheterozygous combination with trx1 : trxM17 > trxZ32 > trxZ16 > trxZ11 > trxM18 = trxJY16 > trxE3.

      (Breen, 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      trxZ32
      Name Synonyms
      Secondary FlyBase IDs
        References (3)