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General Information
Symbol
Dmel\trxZ16
Species
D. melanogaster
Name
FlyBase ID
FBal0032927
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C14271064T

Amino acid change:

R1753W | trx-PA; R1385W | trx-PB; R1385W | trx-PC; R1753W | trx-PD; R1385W | trx-PE

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: R1753W. Residue is in the second half of the highly conserved Cys-rich region.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygote adults show no transformation phenotype. Hemizygotes are pupal lethal, homozygotes are larval lethal. trxZ16/Df(3R)red-P52 hemizygotes show phenotypes that suggest decreased Scr function (transformation of T1 structures to a T2 identity), decreased Ubx function (transformation of T3 to T2), decreased abd-A function (transformation of A2-A7 to A1) and decreased Abd-B function (transformation of posterior abdominal segments to more anterior abdominal identities). Scr group transformations include the development of mesothoracic tibial preapical bristles or mesothoracic tibial apical bristles on the prothoracic tibia, reduced numbers of sex comb teeth (in males), development of sternopleural bristles or katepisternal bristles on the T1 segment. Ubx group transformations include haltere to wing, metathoracic laterotergite to scutum, the development of T3 sternopleural bristles, mesothoracic tibial preapical bristles or mesothoracic tibial apical bristles on the metathoracic tibia. abd-A group transformations include the development of A1 type bristles on abdominal tergites 2 to 3. Abd-B group transformations include the pigmentation of abdominal tergites 5 to 6 in males, and enlargement of abdominal tergite 7. trxE3/trxZ16 flies frequently have missing dorsal head structures, including different combinations of ocelli, ocellar bristles, and postvertical bristles. The posterior border of the A1 tergite may have Uab-like bristles and dark pigmentation. They can also exhibit incomplete dorsal fusion of tergites. The dorsal anal plate of females may be incomplete. trxJY21/trxZ16 flies show mesosternal bristles on T3 and T1, partial transformation of haltere to wing, transformation of dorsal T3 to mesonotum typical of T2, sternopleural bristles in T1 and T3, development of a preapical bristle on T3 and often have abnormal abdominal spiracles and abnormal sternites. Males occasionally develop T2 legs from their genital discs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Partial complementation between hypomorphs produced phenotypes that were weaker than either of the hemizygous or homozygous phenotypes, either rescuing lethality or producing a weaker homeotic transformation phenotype. Transformations range from an average of 0.25 to 14.07 transformations/fly (males were scored for a possible 29 transformations, females were scored for a possible 26 transformations) in different allelic combinations.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

The following alleles form a series of progressively increasing penetrance and expressivity of phenotype when in transheterozygous combination with trx1 : trxM17 > trxZ32 > trxZ16 > trxZ11 > trxM18 = trxJY16 > trxE3.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
trxZ16
Name Synonyms
Secondary FlyBase IDs
    References (3)