FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\trxZ11
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General Information
Symbol
Dmel\trxZ11
Species
D. melanogaster
Name
FlyBase ID
FBal0032923
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Cytology
Description

Amino acid replacement: G3601S. Mutation is in the conserved SET domain.

Amino acid replacement: G3601S. Residue is in the highly conserved C-terminal tromo domain.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

G14265451A

Amino acid change:

G3601S | trx-PA; G3233S | trx-PB; G3233S | trx-PC; G3601S | trx-PD; G3233S | trx-PE

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

27% of type II neuroblast clones in homozygous clones in the larval brain adopt a type I neuroblast identity (as determined by marker expression and the direct generation of ganglion mother cells).

1.3% of heterozygous adults show at least one transformation phenotype. Hemizygotes are pupal lethal, homozygotes are viable, showing a large number of homeotic transformations. trxZ11/Df(3R)red-P52 hemizygotes show phenotypes that suggest decreased Scr function (transformation of T1 structures to a T2 identity), decreased Ubx function (transformation of T3 to T2), decreased abd-A function (transformation of A2-A7 to A1) and decreased Abd-B function (transformation of posterior abdominal segments to more anterior abdominal identities). Scr group transformations include the development of mesothoracic tibial preapical bristles or mesothoracic tibial apical bristles on the prothoracic tibia, reduced numbers of sex comb teeth (in males), development of sternopleural bristles or katepisternal bristles on the T1 segment. Ubx group transformations include haltere to wing, metathoracic laterotergite to scutum, the development of T3 sternopleural bristles, mesothoracic tibial preapical bristles or mesothoracic tibial apical bristles on the metathoracic tibia. abd-A group transformations include, the development of A1 type bristles on abdominal tergites 2 to 3. Abd-B group transformations include, the pigmentation of abdominal tergites 5 to 6 in males, and enlargement of abdominal tergite 7. trx3/trxZ11 adults occasionally developed small heads, anterior thoracic segments, abnormal antennae with reduced aristae and reduced or absent maxillary palps. They also often develop A1 tergites with dark pigmentation and large Uab-like bristles at their posterior borders. The flies have patches of small bristles in the A2 and A3 tergites that are normally only found in the A1 tergite. Transformation of ventral T1 to ventral T2 is seen, and sternopleural bristles are present on T1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

trxZ11 has phenotype, enhanceable by AsxP1

Additional Comments
Genetic Interactions
Statement
Reference

AsxP1 enhances both the penetrance and expressivity of trxZ11.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Partial complementation between hypomorphs produced phenotypes that were weaker than either of the hemizygous or homozygous phenotypes, either rescuing lethality or producing a weaker homeotic transformation phenotype. Transformations range from an average 0.27 to 16.39 transformations/fly (males were scored for a possible 29 transformations, females were scored for a possible 26 transformations) in different allelic combinations.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

The following alleles form a series of progressively increasing penetrance and expressivity of phenotype when in transheterozygous combination with trx1 : trxM17 > trxZ32 > trxZ16 > trxZ11 > trxM18 = trxJY16 > trxE3.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (8)