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General Information
Symbol
Dmel\mod(mdg4)T6
Species
D. melanogaster
Name
FlyBase ID
FBal0046118
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation is in the 67.2 exon.

Amino acid replacement: ?578term.

Nucleotide substitution: at position 137511 of AE003734.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference

ct6, mod(mdg4)T6 has visible phenotype, suppressible by Cp190En15

Enhancer of
Statement
Reference

mod(mdg4)[+]/mod(mdg4)T6 is an enhancer of visible | dominant | homeotic phenotype of brm2, trx[+]/trxE2

mod(mdg4)[+]/mod(mdg4)T6 is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm2, trxE2

mod(mdg4)[+]/mod(mdg4)T6 is an enhancer of visible | dominant | homeotic phenotype of ash1[+]/ash117, trxB11

Suppressor of
Statement
Reference

mod(mdg4)T6 is a suppressor of visible phenotype of ctK

mod(mdg4)T6 is a suppressor of visible phenotype of ct6

mod(mdg4)T6 is a suppressor | partially of visible | recessive phenotype of y2

mod(mdg4)T6 is a suppressor | partially of visible | recessive phenotype of ct6

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

mod(mdg4)T6, trxB11 has haltere phenotype, enhanceable by ash1[+]/ash117

Suppressed by
Statement
Reference

ct6, mod(mdg4)T6 has wing margin phenotype, suppressible by Cp190En15

Suppressor of
Statement
Reference

mod(mdg4)T6 is a suppressor of adult abdomen phenotype of y2

mod(mdg4)T6 is a suppressor of wing margin phenotype of ct6

mod(mdg4)T6 is a suppressor of wing margin phenotype of ctK

mod(mdg4)T6 is a suppressor | partially of wing phenotype of ct6

Other
Additional Comments
Genetic Interactions
Statement
Reference

The wings of ct6; mod(mdg4)T6 mutants have underdeveloped margins.

The wing margin phenotype of ct6; mod(mdg4)T6 mutants is fully suppressed by Cp190En15.

y2 mod(mdg4)T6 double mutant flies have a dappled abdomen with pale bristles.

mod(mdg4)T6 suppresses the "cut" wing phenotype observed in ct6 mutant flies, and the wing margins are fully restored in these animals.

The "cut" wing phenotype observed in ctK mutant animals is suppressed in a mod(mdg4)T6 mutant background.

Body colour: y2 ; mod(mdg4)T6/mod(mdg4)T16 flies have a y- phenotype (yellow bristles, wings and bodies).

mod(mdg4)T6 trxB11 double heterozygotes show a transformation of haltere to wing in 0.3% of cases. Increases the frequency of homeotic transformations seen in trxB11 ash117 double heterozygotes. Increases the frequency of homeotic transformations seen in trxE2 brm2 double heterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments

mod(mdg4)T6 fully complements mod(mdg4)Z3-3401, mod(mdg4)Z3-5578 and mod(mdg4)Z3-3298 with respect to X-Y chromosome nondisjunction in male meiosis.

mod(mdg4)T6/Df(3R)GC14 females do not show increased X chromosome nondisjunction compared to controls and the frequency of recombination in large intervals on the second and third chromosomes in the mutant females is normal.

Member of Group II complementation group. Complementation statement based on transheterozygous phenotype in terms of suppression or non-suppression of y2 and ct6 visible phenotypes.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (4)
References (14)