FlyBase Allele Report: Dmel\mod(mdg4)[T6]

General Information

Symbol

Dmel\mod(mdg4)^T6

Species

D. melanogaster

Name

FlyBase ID

FBal0046118

Feature type

allele

Associated gene

Dmel\mod(mdg4)

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Gerasimova et al., 1995)

Mutagen

ethyl methanesulfonate

(Mongelard et al., 2002, Gerasimova and Corces, 1998, Gerasimova et al., 1995)

Progenitor genotype

Cytology

Description

Mutation is in the 67.2 exon.

(Soltani-Bejnood et al., 2007)

Amino acid replacement: ?578term.

(Soltani-Bejnood et al., 2007)

Nucleotide substitution: at position 137511 of AE003734.

(Mongelard et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female fertile (with Df(3R)GC14)

(Soltani-Bejnood et al., 2007)

lethal - all die during embryonic stage | recessive

(Gerasimova et al., 1995)

some die during embryonic stage | recessive

(Gerasimova et al., 1995)

viable

(Soltani-Bejnood et al., 2007, Mongelard et al., 2002)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ash1¹⁷, mod(mdg4)^T6 has visible | homeotic phenotype, enhanceable by trx^B11

(Gerasimova and Corces, 1998)

mod(mdg4)^T6, trx^B11 has visible | dominant | homeotic phenotype, enhanceable by ash1[+]/ash1¹⁷

(Gerasimova and Corces, 1998)

Suppressed by

Statement

Reference

ct⁶, mod(mdg4)^T6 has visible phenotype, suppressible by Cp190^En15

(Oliver et al., 2010)

Enhancer of

Statement

Reference

Df(3R)GC14/mod(mdg4)^T6 is an enhancer of abnormal body color phenotype of y²

(Soltani-Bejnood et al., 2007)

mod(mdg4)[+]/mod(mdg4)^T6 is an enhancer of visible | dominant | homeotic phenotype of brm², trx[+]/trx^E2

(Gerasimova and Corces, 1998)

mod(mdg4)[+]/mod(mdg4)^T6 is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Gerasimova and Corces, 1998)

mod(mdg4)[+]/mod(mdg4)^T6 is an enhancer of visible | dominant | homeotic phenotype of ash1[+]/ash1¹⁷, trx^B11

(Gerasimova and Corces, 1998)

Suppressor of

Statement

Reference

mod(mdg4)^T6 is a suppressor of abnormal body color phenotype of y²

(Golovnin et al., 2008)

mod(mdg4)^T6 is a suppressor of visible phenotype of ct⁶

(Golovnin et al., 2008)

mod(mdg4)^T6 is a suppressor of visible phenotype of ct^K

(Golovnin et al., 2008)

mod(mdg4)^T6 is a suppressor of visible | recessive phenotype of y²

(Mongelard et al., 2002)

mod(mdg4)^T6 is a suppressor of visible | recessive phenotype of ct⁶

(Mongelard et al., 2002)

mod(mdg4)^T6 is a suppressor of abnormal body color | recessive phenotype of y²

(Mongelard et al., 2002)

Other

Statement

Reference

mod(mdg4)^T6, trx^B11 has visible | dominant | homeotic phenotype

(Gerasimova and Corces, 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

mod(mdg4)^T6, trx^B11 has haltere phenotype, enhanceable by ash1[+]/ash1¹⁷

(Gerasimova and Corces, 1998)

Suppressed by

Statement

Reference

mod(mdg4)^T6, y² has adult cuticle phenotype, suppressible | partially by Cp190^En15

(Oliver et al., 2010)

ct⁶, mod(mdg4)^T6 has wing margin phenotype, suppressible by Cp190^En15

(Oliver et al., 2010)

Suppressor of

Statement

Reference

mod(mdg4)^T6 is a suppressor of adult abdomen phenotype of y²

(Golovnin et al., 2008)

mod(mdg4)^T6 is a suppressor of wing margin phenotype of ct⁶

(Golovnin et al., 2008)

mod(mdg4)^T6 is a suppressor of wing margin phenotype of ct^K

(Golovnin et al., 2008)

mod(mdg4)^T6 is a suppressor of adult epidermis phenotype of y²

(Mongelard et al., 2002)

mod(mdg4)^T6 is a suppressor of wing phenotype of ct⁶

(Mongelard et al., 2002)

Other

Statement

Reference

ct⁶, mod(mdg4)^T6 has wing margin phenotype

(Oliver et al., 2010)

mod(mdg4)^T6, y² has abdominal tergite marginal bristle phenotype

(Golovnin et al., 2008)

mod(mdg4)^T16/mod(mdg4)^T6, y² has chaeta phenotype

(Soltani-Bejnood et al., 2007)

mod(mdg4)^T6, trx^B11 has haltere phenotype

(Gerasimova and Corces, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The wings of ct⁶; mod(mdg4)^T6 mutants have underdeveloped margins.

The wing margin phenotype of ct⁶; mod(mdg4)^T6 mutants is fully suppressed by Cp190^En15.

(Oliver et al., 2010)

y² mod(mdg4)^T6 double mutant flies have a dappled abdomen with pale bristles.

mod(mdg4)^T6 suppresses the "cut" wing phenotype observed in ct⁶ mutant flies, and the wing margins are fully restored in these animals.

The "cut" wing phenotype observed in ct^K mutant animals is suppressed in a mod(mdg4)^T6 mutant background.

(Golovnin et al., 2008)

Body colour: y² ; mod(mdg4)^T6/mod(mdg4)^T16 flies have a y^- phenotype (yellow bristles, wings and bodies).

(Soltani-Bejnood et al., 2007)

mod(mdg4)^T6 trx^B11 double heterozygotes show a transformation of haltere to wing in 0.3% of cases. Increases the frequency of homeotic transformations seen in trx^B11 ash1¹⁷ double heterozygotes. Increases the frequency of homeotic transformations seen in trx^E2 brm² double heterozygotes.

(Gerasimova and Corces, 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

mod(mdg4)^Z3-3401

(Soltani-Bejnood et al., 2007)

mod(mdg4)^Z3-5578

(Soltani-Bejnood et al., 2007)

mod(mdg4)^Z3-3298

(Soltani-Bejnood et al., 2007)

mod(mdg4)^L3101

(Mongelard et al., 2002)

mod(mdg4)^neo129

(Mongelard et al., 2002)

mod(mdg4)⁰³⁸⁵²

(Mongelard et al., 2002)

Fails to complement

mod(mdg4)^ul

(Mongelard et al., 2002)

Comments

mod(mdg4)^T6 fully complements mod(mdg4)^Z3-3401, mod(mdg4)^Z3-5578 and mod(mdg4)^Z3-3298 with respect to X-Y chromosome nondisjunction in male meiosis.

mod(mdg4)^T6/Df(3R)GC14 females do not show increased X chromosome nondisjunction compared to controls and the frequency of recombination in large intervals on the second and third chromosomes in the mutant females is normal.

(Soltani-Bejnood et al., 2007)

Member of Group II complementation group. Complementation statement based on transheterozygous phenotype in terms of suppression or non-suppression of y² and ct⁶ visible phenotypes.

(Mongelard et al., 2002)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF214649

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

ModΔC

(Golovnin et al., 2008)

(Soltani-Bejnood et al., 2007)

mod(mdg4)^T6

(Ong and Lin, 2018, Melnikova et al., 2017, Melnikova et al., 2017, King et al., 2014, Ong et al., 2013, Oliver et al., 2010, Golovnin et al., 2008, Golovnin et al., 2008, Melnikova et al., 2004, Pai et al., 2004)

modifier of mdg4^T6

(Quijano et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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