FlyBase Allele Report: Dmel\Cp190[En15]

General Information

Symbol

Dmel\Cp190^En15

Species

D. melanogaster

Name

FlyBase ID

FBal0288495

Feature type

allele

Associated gene

Dmel\Cp190

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Oliver et al., 2010)

Progenitor genotype

Cytology

Description

Amino acid replacement: Y571term.

(Oliver et al., 2010)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:15,272,681..15,272,681 [-]

Nucleotide change:

C15272681G

Reported nucleotide change:

C1889G

Amino acid change:

Y571term | Cp190-PA; Y571term | Cp190-PB

Reported amino acid change:

Y571term

(Oliver et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

homeotic (with Cp190³)

(Savitsky et al., 2016)

homeotic (with Cp190^P1)

(Savitsky et al., 2016)

majority die during pharate adult stage (with Cp190³)

(Savitsky et al., 2016)

majority die during pharate adult stage (with Cp190^P1)

(Savitsky et al., 2016)

partially lethal - majority die (with Cp190³)

(Savitsky et al., 2016)

partially lethal - majority die (with Cp190^P1)

(Savitsky et al., 2016)

Phenotype Manifest In

abdominal segment 1 (with Cp190³)

(Savitsky et al., 2016)

abdominal segment 1 (with Cp190^P1)

(Savitsky et al., 2016)

abdominal segment 2 (with Cp190³)

(Savitsky et al., 2016)

abdominal segment 2 (with Cp190^P1)

(Savitsky et al., 2016)

abdominal sternite bristle (with Cp190^P1)

(Savitsky et al., 2016)

abdominal tergite (with Cp190³)

(Savitsky et al., 2016)

abdominal tergite (with Cp190^P1)

(Savitsky et al., 2016)

wing (with Cp190³)

(Savitsky et al., 2016)

wing (with Cp190^P1)

(Savitsky et al., 2016)

Detailed Description

Statement

Reference

The majority of Cp190^En15/Cp190³ flies die as pharate adults, with rare (2%) escapers that die shortly after hatching, and pharate adults show homeotic transformation of abdominal segment A1 into A2 (but no transformations in segments A6-A8): held out wings in escapers are often blistered, the shape of t1 (tergite of the first segment) is changed toward t2, t1 bears long bristles, inner support sclerite is absent or rudimentary, s1 (sternite of the first segment) is often visible but without bristles. Cp190^P1/Cp190^En15 flies show similar phenotypes to Cp190^P1/Cp190³ except with slightly more escapers (5%) and s1 usually shows bristles.

(Savitsky et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cp190^En15 is a suppressor of visible phenotype of ct⁶, mod(mdg4)^T6

(Oliver et al., 2010)

Cp190^En15/Cp190^P11 is a suppressor of visible phenotype of ct⁶

(Oliver et al., 2010)

Cp190^En15/Cp190^P11 is a suppressor of visible phenotype of y²

(Oliver et al., 2010)

Other

Statement

Reference

CTCF^GE24185, Cp190^P1/Cp190^En15 has partially lethal - majority die phenotype

(Savitsky et al., 2016)

CTCF^GE24185, Cp190^P1/Cp190^En15 has homeotic phenotype

(Savitsky et al., 2016)

CTCF^GE24185, Cp190^P1/Cp190^En15 has majority die during pharate adult stage phenotype

(Savitsky et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cp190^En15 is a suppressor | partially of adult cuticle phenotype of mod(mdg4)^T6, y²

(Oliver et al., 2010)

Cp190^En15 is a suppressor of wing margin phenotype of ct⁶, mod(mdg4)^T6

(Oliver et al., 2010)

Cp190^En15/Cp190^P11 is a suppressor of wing margin phenotype of ct⁶

(Oliver et al., 2010)

Cp190^P1/Cp190^En15 is a suppressor of wing margin phenotype of ct⁶

(Oliver et al., 2010)

Cp190^En15/Cp190^P11 is a suppressor of adult cuticle phenotype of y²

(Oliver et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

The majority of CTCF^GE24185 Cp190^En15 /CTCF^GE24185 Cp190^P1 double mutants die as pharate adults, with rare (2%) weak escapers that show homeotic transformation of abdominal segment A1 into A2 (less pronounced than in Cp190^En15/Cp190^P1) and A6-A8 (A6/7 transformations weaker than in CTCF^GE24185/CTCF^GE24185, though A8 transformation is enhanced): the shape of t1 is changed toward t2 though large bristles are rare, s1 usually shows no bristles, t1 bristles are more uniform than wild type; in males s6 has 0-4 (average 1) bristles, t7 is enlarged and often developed to only one side in 50% of males, t8 is well separated from t9 and usually visible with a bunch of large bristles, and genitalia is rotated 90-180[o] (100%); in females s7 has 5-11 (average 8) bristles, the shape of s7 is transformed towards s6 and bristles lose orientation, t8 always has 7-19 (average 13) large bristles (often forming two rows).

(Savitsky et al., 2016)

The wing margin phenotype of ct⁶ mutants is partially suppressed by Cp190^En15/Cp190^P11.

The cuticle colour of y²; Cp190^En15/Cp190^P11 adults is darker than that of y² flies.

The wing margin phenotype of ct⁶; mod(mdg4)^T6 mutants is fully suppressed by Cp190^En15.

y² Cp190^En15/+, mod(mdg4)^T6 flies have more darkly pigmented body cuticle and wings than y²; mod(mdg4)^T6 flies.

(Oliver et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CP190^E15

(Oliver et al., 2010)

CP190^En15

(Oliver et al., 2010)

Cp190^EN15

(Savitsky et al., 2016)

Cp190^En15

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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