His2Av810/Df(3R)BSC524 does not suppress the excess of germline stem cell (GSC)-like cells seen in larval testes when upd1Scer\UAS.cZa is expressed under the control of Scer\GAL4nos.UTR.T:Hsim\VP16, although a few germ cell cysts with branched fusomes are seen.
One copy of domk08108 enhances the loss of His2Av810 mutant germline stem cells in the testis. A greater proportion of testes contain His2Av810 domk08108/+ mutant GSC clones than with His2Av810 alone.
CG86773602/+ ; His2Av810/+ double heterozygotes show a synergistic effect on the position effect variegation at the w locus caused by In(1)wm4h, showing strong suppression of position effect variegation.
His2Av810/+ enhances the frequency of transformation of the second or third leg to first leg that is seen in Df(3L)Pc/+ flies; 18% of the double heterozygous males have sex combs on the second leg and 72% of the double heterozygous males have sex combs on both the second and third legs (compared to 14.5% of Df(3L)Pc/+ males having sex combs on the second and/or third legs). The frequency of the appearance of an apical bristle on the third leg decreases to 29% in ash117 trxB11 His2Av810 triple heterozygotes compared to ash117 trxB11 double heterozygotes.
Mutant phenotype can be rescued by P element mediated transformation of a wild type copy of His2Av.
Encodes Hist-2AV, a variant form.