FB2026_02 , released June 18, 2026
Allele: Dmel\His2Av+t4.0
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General Information
Symbol
Dmel\His2Av+t4.0
Species
D. melanogaster
Name
FlyBase ID
FBal0098385
Feature type
allele
Associated gene
Dmel\His2Av
Associated Insertion(s)
Carried in Construct
P{His2AvD+t4.0}
Key Links
Transgenic product class
genomic_DNA
(Clarkson et al., 1999)
wild_type
(Clarkson et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Clarkson et al., 1999)
wild_type
(Clarkson et al., 1999)
Mutagen
in vitro construct
(Clarkson et al., 1999)
Progenitor genotype
Carried in construct
P{His2AvD+t4.0}
Cytology
Description

A 4.0kb genomic fragment containing His2Av.

(Clarkson et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
His2Av
Encoded product / tool
His2Av
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Imaginal discs from larvae expressing His2AvtCT in a His2Av810 background have significantly more radiation-induced apoptotic cells than do discs from control larvae expressing His2Av+t4.0 in a His2Av810 background. This increase in radiation-induced apoptosis does not result in an increase in lethality. In the absence of radiation, both types of imaginal discs have a similar number of apoptotic cells.

      (Madigan et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      His2Av+t4.0
      His2AvD+t4.0
      Name Synonyms
      wild type
      (Clarkson et al., 1999)
      Secondary FlyBase IDs
        References (3)