FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Asx8
Open Close
General Information
Symbol
Dmel\Asx8
Species
D. melanogaster
Name
FlyBase ID
FBal0029008
Feature type
allele
Associated gene
Dmel\Asx
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Milne et al., 1999, Sinclair et al., 1992)
Mutagen
gamma ray
(Sinclair et al., 1992)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      More severe Asx phenotype than Asx- deletion and also a more severe transformation of thoracic segments towards abdominal segments. Segmentation defects are also present: missing segments, midline denticles and hemisegments. Hemizygous embryos have weak head and thoracic defects and weak abdominal homeotic transformations. Heterozygous adults have a mild transformation of A4 to A5 in males.

      (Sinclair et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Asx8 is an enhancer of sex comb phenotype of Pc4

      (Milne et al., 1999)
      NOT Enhancer of
      Statement
      Reference

      Asx8 is a non-enhancer of phenotype of trxB11

      (Milne et al., 1999)
      NOT Suppressor of
      Statement
      Reference

      Asx8 is a non-suppressor of phenotype of trxB11

      (Milne et al., 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Does not significantly enhance the trx-G homeotic transformations of Df(3R)red1 or trxB11, nor suppress anterior transformations due to Df(3R)red1 or trxB11. Strongly enhances the extra sex comb phenotype of Pc4.

      (Milne et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Asx8
      Name Synonyms
      Secondary FlyBase IDs
        References (3)