Open Close
General Information
Symbol
Dmel\Su(z)21
Species
D. melanogaster
Name
FlyBase ID
FBal0028569
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G12999995Y

Amino acid change:

L120F | Su(z)2-PA; L120F | Su(z)2-PB; L120F | Su(z)2-PC

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Nucleotide change:

A13001119T

Amino acid change:

K284term | Su(z)2-PA; K284term | Su(z)2-PB; K284term | Su(z)2-PC

Reported amino acid change:

K284term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Amino acid replacement: L120F.

The nonsense mutation occurs shortly after the the HTH domain and is expected to produce a truncated protein.

Amino acid replacement: K284term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One copy of Su(z)21 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)wm4.

One copy of Su(z)21 is unable to suppress the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

Su(z)21 shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosome.

Suppresses z1 in In(1)wm4 and In(1)rst3 but has little effect on zv77h in these combinations. Suppressor of z1 wzl, zv77h wzl and z1 wzm but has no effect on zv77h wzm.

Chaetae loss phenotype of Su(z)21/Df(2R)vg62 or Su(z)21/Df(2R)vg-D is stronger than for Su(z)24/Df(2R)vg62 or Su(z)24/Df(2R)vg-D. Hemizygotes die as larvae/pupae.

No homeotic phenotype and the mutation cannot enhance the homeotic phenotypes of Pc group mutants (FBrf0049524).

In z1 wzm strain mutation causes reduction of eye pigmentation. Slightly suppress w phenotype in a e(y) background.

Heterozygotes with Df(2R)vg62 and with Df(2R)vg-D exhibit enhanced depilate phenotypes.

Heterozygotes have reduced viability. Fertile at 25oC.

zeste-->red eyes

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Su(z)21/Su(z)2[+] is an enhancer of visible phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU

Su(z)21/Su(z)2[+] is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm2, trxE2

Su(z)21/Su(z)2[+] is an enhancer of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]

Suppressor of
Statement
Reference

Su(z)21/Su(z)2[+] is a suppressor of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU

Su(z)21/Su(z)2[+] is a suppressor | partially of visible phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4ptc-559.1

Su(z)21 is a suppressor of abnormal eye color phenotype of z1

Other
Phenotype Manifest In
Enhancer of
Statement
Reference

Su(z)21/Su(z)2[+] is an enhancer of eye phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU

Su(z)21/Su(z)2[+] is an enhancer of adult metathoracic segment phenotype of brm[+]/brm2, trxE2

Su(z)21/Su(z)2[+] is an enhancer of adult metathoracic segment phenotype of ash117, trxB11/trx[+]

Suppressor of
Statement
Reference

Su(z)21 is a suppressor of eye phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4GMR.PU

Su(z)21 is a suppressor of phenotype of z1

Su(z)21/Su(z)2[+] is a suppressor of phenotype of z1

Other
Additional Comments
Genetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is ameliorated by combination with a single copy of Su(z)21.

Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males, but acts as a meiotic drive suppressor, suppressing drive against the X and Y chromosomes in these flies. Suppresses meiotic drive of the Y chromosome in Df(1)X-1 males compared to controls.

The addition of Su(z)21 suppresses the Pairing sensitive silencing effect seen in wMcp.scs'.21 and wMcp.y.scs'.1 and strongly suppresses the eye colour phenotype of double insertion combinations of wMcp.scs'.21/ywe.Mcp.1 (P{Mcp-w#21}124/+, P{Mcp-wy#1}183/+) and wMcp.y.scs'.1/ywe.Mcp.2 (P{Mcp-yw#1}103/+, P{Mcp-wy#2}50/+).

Has no effect on the phenotypes of ct2s, ct4s and ct6, where the wing margin enhancer is completely blocked, or ctpN2s or ctn2s.

Complete suppression of z1 phenotype, eyes are wild-type in colour. Eye color of heterozygous females which are also z1/z1 : wild type. Eye color of heterozygous males which are also z1, wis/Y: wild type.

Dominant suppressor of z1 interaction with w.

Dominant suppressor of the z1 interaction with w.

Heterozygous flies modify the yellow eyes of z1 to red: dominant suppressors of z1 eye colour.

Very strong suppression of the z/w interaction causing darkening of the eye pigmentation.

Xenogenetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is exacerbated by combination with a single copy of Su(z)21.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Rasmuson.

Comments
Comments

Fails to complement: Psc1. Complements: PscArp.1. Complements: Psc1.d20. Complements: Psc14P4. Complements: Su(z)31. Fails to complement: Su(z)31.y. Complements: l(2)49Dc1.

Lethal when heterozygous with Psc1. Recombinationally mapped distal to distal breakpoint of Df(2R)vg62.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Su(z)21
Su(z)2
Name Synonyms
Secondary FlyBase IDs
  • FBal0013981
References (32)