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General Information
Symbol
Dmel\Su(z)21.b7
Species
D. melanogaster
Name
FlyBase ID
FBal0028570
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Amino acid replacement: K284term.

Carries the nonsense mutation of its progenitor (Su(z)21) as well as a ~3.5kb deletion of the first two exons and a 4bp insertion (TTCT) at the site of the deletion. The putative TATA box is preserved 8bp upstream of the breakpoint, consistent with this allele being competent for transcription. (It is not known whether Su(z)21.b7 also carries the L120F mutation found in Su(z)21.)

2kb deletion at the 5' end of the Su(z)2 promoter.

2kb deletion from 0 to +2 on the molecular map.

2 kb deletion at 5' end of transcription unit

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One copy of Su(z)21.b7 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)wm4.

One copy of Su(z)21.b7 moderately suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

Su(z)21.b7 can show a strong dominant suppression on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w+mW.hs allele at the telomeres of the second and third chromosome. Has no effect on pericentric and fourth chromosome insertions.

Mutation does not affect the level of w expression in ph-plac+3 flies.

Cuticles of embryos lacking both zygotic and maternal Su(z)2 contribution show no defects apart from occasional head defects.

Isolated on the basis of reverting the dominant z1 eye color suppression associated with Su(z)21. In a z1, wis/Y background, Su(z)21.b7 produces an orange eye colour similar to that found in z1, wis/Y;+/+. The reversion event simultaneously reverted the ability of Su(z)21 to enhance the dominant loss of chaetae phenotype associated with Su(z)2vg62 (Df(2R)vg62) and Su(z)2vgD (Df(2R)vg-D). Heterozygotes with Df(2R)vg-D are viable. Hemizygotes die as larvae/pupae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Su(z)21.b7/Su(z)2[+] is an enhancer of visible phenotype of E2f1UAS.cNa, Scer\GAL4Act88F.PD

NOT Enhancer of
Statement
Reference

Su(z)21.b7/Su(z)2[+] is a non-enhancer of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU

Su(z)21.b7/Su(z)2[+] is a non-enhancer of visible phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

Su(z)21.b7/Su(z)2[+] is a non-suppressor of visible | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU

Su(z)21.b7/Su(z)2[+] is a non-suppressor of visible phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU

Phenotype Manifest In
Enhancer of
Statement
Reference

Su(z)21.b7/Su(z)2[+] is an enhancer of wing phenotype of E2f1UAS.cNa, Scer\GAL4Act88F.PD

NOT Enhancer of
Statement
Reference

Su(z)21.b7/Su(z)2[+] is a non-enhancer of eye phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

Su(z)21.b7/Su(z)2[+] is a non-suppressor of wing vein | adult stage phenotype of Marcal1UAS.cBa, Scer\GAL4Tub.PU

Su(z)21.b7/Su(z)2[+] is a non-suppressor of eye phenotype of DpUAS.cDa, E2f1UAS.cNa, Scer\GAL4GMR.PU

Additional Comments
Genetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1Scer\UAS.cBa under the control of Scer\GAL4tub.PU is not affected by combination with a single copy of Su(z)21.b7.

Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males, but acts as a meiotic drive suppressor, suppressing drive against the X and Y chromosomes in these flies.

Xenogenetic Interactions
Statement
Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1Scer\UAS.cBa under the control of Scer\GAL4Bx-MS1096 is not affected by combination with a single copy of Su(z)21.b7.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer

Wu.

Revertant.

Comments
Comments

Complements: Psc1. Complements: PscArp.1.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
  • FBal0013982
References (20)