FlyBase Allele Report: Dmel\Su(z)2[eos]

General Information

Symbol

Dmel\Su(z)2^eos

Species

D. melanogaster

Name

out there somewhere

FlyBase ID

FBal0045169

Feature type

allele

Associated gene

Dmel\Su(z)2

Associated Insertion(s)

Carried in Construct

Also Known As

Su(z)2D^eos

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Wu and Howe, 1995)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Wu and Howe, 1995)

Description

Amino acid replacement: Q448term.

(Emmons et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:13,001,611..13,001,611 [+]

Nucleotide change:

C13001611T

Amino acid change:

Q448term | Su(z)2-PA; Q448term | Su(z)2-PB; Q448term | Su(z)2-PC

Reported amino acid change:

Q448term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Emmons et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(2R)Su(z)2-1.b8)

(Emmons et al., 2009)

lethal | recessive

(Wu and Howe, 1995)

non-suppressor of variegation | dominant, with In(1)w^m4

(Doheny et al., 2008)

partially lethal - majority die (with Su(z)2^1.b7)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2¹)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^4-34)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^s15)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^s84)

(Emmons et al., 2009)

partially lethal - majority die (with Su(z)2^s95)

(Emmons et al., 2009)

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

(Doheny et al., 2008)

viable (with Su(z)2^s20)

(Emmons et al., 2009)

viable (with Su(z)2^s21)

(Emmons et al., 2009)

viable (with Su(z)2^s36)

(Emmons et al., 2009)

viable (with Su(z)2^sM)

(Emmons et al., 2009)

Phenotype Manifest In

pigment cell

(Wu and Howe, 1995)

Detailed Description

Statement

Reference

One copy of Su(z)2^eos is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)w^m4.

One copy of Su(z)2^eos moderately suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

(Doheny et al., 2008)

Shows no dominant effect on telomeric Position Effect Variegation (PEV) in stocks carrying a variegating w^+mW.hs allele at the telomeres of the second and third chromosomes.

(Cryderman et al., 1999)

Hemizygotes die as larvae/pupae.

(Wu and Howe, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Su(z)2^eos is a suppressor of phenotype of z¹

(Wu and Howe, 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Has no effect on the frequency of X-Y chromosome nondisjunction seen in Df(1)X-1-53B males, but acts as a meiotic drive suppressor, suppressing drive against the X and Y chromosomes in these flies.

(McKee et al., 2000)

Suppression of z¹ eye color, towards wild-type colour. Eye color of heterozygous females which are also z¹/z¹ : maroon. Eye color of heterozygous males which are also z¹, w^is/Y: maroon.

(Wu and Howe, 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Su(z)2^sM

(Emmons et al., 2009)

Su(z)2^s36

(Emmons et al., 2009)

Su(z)2^s21

(Emmons et al., 2009)