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General Information
Symbol
Dmel\Su(z)23-1
Species
D. melanogaster
Name
FlyBase ID
FBal0030292
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Su(z)31
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Inserted_sequence:

G

Comment:

The insertion of a "G" at this point leads to a frameshift and early translation termination.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

A 'G' is inserted after nucleotide position 1873, resulting in a seven-amino-acid frameshift followed by a nonsense codon.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One copy of Su(z)23-1 is unable to suppress position effect variegation (PEV) at the w locus caused by In(1)wm4.

One copy of Su(z)23-1 moderately suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

Hemizygotes die as larvae/pupae.

Heterozygotes have reduced viability. Fertile at 25oC.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

Su(z)2[+]/Su(z)23-1 is an enhancer of visible phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4GMR.PU

Su(z)2[+]/Su(z)23-1 is an enhancer of visible phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4ptc-559.1

Suppressor of
Statement
Reference

Su(z)2[+]/Su(z)23-1 is a suppressor | partially of visible phenotype of E2f1UAS.cNa, Scer\GAL4Act88F.PD

Phenotype Manifest In
Enhancer of
Statement
Reference

Su(z)2[+]/Su(z)23-1 is an enhancer of eye phenotype of E2f1dsRNA.UAS.cJa, Scer\GAL4GMR.PU

Suppressor of
Statement
Reference

Su(z)2[+]/Su(z)23-1 is a suppressor | partially of wing phenotype of E2f1UAS.cNa, Scer\GAL4Act88F.PD

Additional Comments
Genetic Interactions
Statement
Reference

Suppression of z1 eye color, towards wild-type colour. Eye color of heterozygous females which are also z1/z1 : maroon (with speckling). Eye color of heterozygous males which are also z1, wis/Y: maroon.

Dominant suppressor of z1 interaction with w.

Very strong suppression of the z/w interaction causing darkening of the eye pigmentation.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Complements: Psc1. Complements: PscArp.1. Complements: Su(z)21. Complements: Su(z)2Arp.1.

Viable in trans to alleles of Psc and Su(z)2, though in some cases viability is reduced. Su(z)31 and Su(z)3eos show partial complementation.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
suppressor of zeste 3
Secondary FlyBase IDs
    References (8)