Homozygous wing and haltere discs are generally smaller than wild type in larvae that have been allowed to complete embryogenesis at the permissive temperature of 18oC and have then been reared at the restrictive temperature of 30oC for 96 hours.
E(z)61 animals derived from eggs laid at 18oC, incubated for an additional 24 hours at 18oC and then transferred to 29oC reach puparium formation and some of them pass through pupal moulting before dying.
Does not cause a small disc phenotype.
Mutation does not affect the level of w expression in ph-plac+3 flies.
Embryos at 29oC display strong posteriorly directed homeotic transformations in which virtually all segments bear eighth abdominal segment-like denticles. Zygotic reduction or loss of trx+ fails to suppress the maternal effect to viability, total loss of zygotic trx+ activity dramatically suppresses maternal effect homeotic transformations.
Homozygous embryos collected over 48 hours at 23oC and then raised at 29oC to the third larval instar show larger, thicker, puffier, less contrasty salivary chromosomes, as if they are decondensed. Chromosome bands are less easy to read because fainter and many characteristic constrictions are absent. Binding of Psc, z and Su(z)2 proteins is dramatically reduced, with remaining binding sites tending to be those that are shared by all three proteins, the z and the polyhomeotic gene products. Psc and Su(z)2 proteins are not lost at the restrictive temperature, just dissociated from the chromatin.
Heterozygous embryos are extremely transformed but there is some phenotypic rescue by abd-A and Abd-B primarily in the head, Abd-B accumulation becomes patchy.
E(z)60/E(z)61 heterozygotes die as pharate adults. At the restrictive temperature embryos from homozygous females die with most body segments transformed towards the eighth abdominal state.
Dominant suppressor of z mutants.