FlyBase Allele Report: Dmel\aurA[87Ac-3]

General Information

Symbol

Dmel\aurA^87Ac-3

Species

D. melanogaster

Name

FlyBase ID

FBal0000804

Feature type

allele

Associated gene

Dmel\aurA

Associated Insertion(s)

Carried in Construct

Also Known As

aur^87Ac-3

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Glover et al., 1995)

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates pancreatic ductal adenocarcinoma

modeled by CycE^{UAS.Tag:HA.Medsh}, Med^{RNAi.UAS.CycE-HA}, p53^{RNAi.UAS.RasG12D}

(Sekiya et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

chromosome | third instar larval stage (with aurA⁹⁴⁹)

(Merigliano et al., 2019)

eo neuron (with aurA³⁷)

(Berdnik and Knoblich, 2002)

larval brain | larval stage (with aurA³⁷)

(Wirtz-Peitz et al., 2008)

larval brain | third instar larval stage (with aurA⁹⁴⁹)

(Merigliano et al., 2019)

larval neuroblast (with aurA³⁷)

(Wirtz-Peitz et al., 2008)

neuroblast | supernumerary & brain

(Lee et al., 2006)

neuroblast | third instar larval stage (with aurA⁹⁴⁹)

(Merigliano et al., 2019)

primordial germ cell (with aurA³)

(Lerit and Gavis, 2011)

thecogen cell (with aurA³⁷)

(Berdnik and Knoblich, 2002)

tormogen cell | ectopic (with aurA³⁷)

(Berdnik and Knoblich, 2002)

trichogen cell | ectopic (with aurA³⁷)

(Berdnik and Knoblich, 2002)

Detailed Description

Statement

Reference

aurA⁹⁴⁹/aurA^87Ac-3 transheterozygous third instar larval brain neuroblasts show some chromosomal aberrations and aneuploidy/polyploidy, which are almost absent in controls.

(Merigliano et al., 2019)

aur³/aur^87Ac-3 embryos have a reduced number of pole cells compared to controls and the pole cells that do form often have greatly reduced germ plasm.

(Lerit and Gavis, 2011)

aur³⁷/aur^87Ac-3 larval brain neuroblasts show overproliferation.

(Wirtz-Peitz et al., 2008)

aur^87Ac-5/aur^87Ac-3 larval brain neuroblasts show very few normal metaphase and anaphase figures, and many circular mitotic figures.

(Glover et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

aurA^87Ac-3/aurA³⁷ has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^insc-Mz1407/baz^UASp.GFP

(Wirtz-Peitz et al., 2008)

Suppressor of

Statement

Reference

aurA^87Ac-3 is a suppressor | partially of increased mortality during development phenotype of CycE^{UAS.Tag:HA.Medsh}, Med^{RNAi.UAS.CycE-HA}, Ras85D^{G12D.UAS.p53sh}, Scer\GAL4^Ser.PU, p53^{RNAi.UAS.RasG12D}

(Sekiya et al., 2023)

aurA^87Ac-3/aur[+] is a suppressor of abnormal mitotic cell cycle | somatic clone phenotype of jub^E1

(Sabino et al., 2011)

Other

Statement

Reference

aurA^87Ac-3/aurA[+], wts^x1 has abnormal neuroanatomy | embryonic stage phenotype

(Keder et al., 2015)

aurA^87Ac-3/aur[+], sub¹³¹/sub¹ has viable | larval stage phenotype

(Cesario et al., 2006)

Phenotype Manifest In

Suppressed by

Statement

Reference

aurA^87Ac-3/aurA³⁷ has larval neuroblast phenotype, suppressible by Scer\GAL4^insc-Mz1407/baz^UASp.GFP

(Wirtz-Peitz et al., 2008)

aurA^87Ac-3/aurA³⁷ has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/baz^UASp.GFP

(Wirtz-Peitz et al., 2008)

Enhancer of

Statement

Reference

aurA^87Ac-3 is an enhancer of adult abdominal segment 4 | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

aurA^87Ac-3 is an enhancer of adult abdominal segment 5 phenotype of E(z)^Trm

(Bajusz et al., 2001)

aurA^87Ac-3 is an enhancer of adult mesothoracic segment | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

aurA^87Ac-3 is an enhancer of adult metathoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

Suppressor of

Statement

Reference

aurA^87Ac-3/aur[+] is a suppressor of centrosome | somatic clone phenotype of jub^E1

(Sabino et al., 2011)

aurA^87Ac-3/aur[+] is a suppressor of spindle | somatic clone phenotype of jub^E1

(Sabino et al., 2011)

aurA^87Ac-3/aur[+] is a suppressor of neuroblast | somatic clone phenotype of jub^E1

(Sabino et al., 2011)

Other

Statement

Reference

aurA^87Ac-3/aurA[+], wts^x1 has larval RP2 motor neuron | embryonic stage phenotype

(Keder et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The proportion of hemisegments with abnormal number of neurons in the asymmetrically dividing RP2 neural lineage is significantly increased in wts^x1/+;aurA^87Ac-3/+ double heterozygous embryos compared to either of the single heterozygotes or wild type.

(Keder et al., 2015)

The percentage of abnormal spindles in jub^E1 mutants is suppressed by removing one copy of aur because in jub^E1, aur^87Ac-3 double mutant cells the total number of spindle defects is decreased from 45% to 34%.

(Sabino et al., 2011)

The overproliferation of larval brain neuroblasts seen in aur³⁷/aur^87Ac-3 animals is suppressed by expression of baz^{Scer\UAS.P\T.T:Avic\GFP} under the control of Scer\GAL4¹⁴⁰⁷.

(Wirtz-Peitz et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

aurA³

(Glover et al., 1995)

Fails to complement

aurA³⁷

(Berdnik and Knoblich, 2002)

Comments

aur³⁷/aur^87Ac-3 is a lethal combination.

(Berdnik and Knoblich, 2002)

Images (0)

Mutant

Wild-type

Stocks (2)

6188

108673

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

aur-A^87Ac3

(Merigliano et al., 2019)

aur¹⁷⁰

(Sabino et al., 2011)

aur^87Ac-3

(Keder et al., 2015, Cesario et al., 2006)

aurA^87Ac-3

(Sekiya et al., 2023, Zheng et al., 2020, Das et al., 2016, Bell et al., 2015, Besson et al., 2015, Moon and Matsuzaki, 2013, Lerit and Gavis, 2011, Wang et al., 2009, Lee et al., 2006)

aurA^Ac-3

(Wirtz-Peitz et al., 2008, Wirtz-Peitz et al., 2008)

ck10^e170

(Glover et al., 1995)

e¹⁷⁰

(Gausz et al., 1981)

l(3)87Ac³

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

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