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General Information
Symbol
Dmel\ash11
Species
D. melanogaster
Name
FlyBase ID
FBal0000731
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a C after nucleotide 4108, causing a frame shift at amino acid residue 1032.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ash11 flies show a haltere to wing transformation.

Lethality occurs during the larval and pupal stages. Double heterozygotes with Ubxabx-1, trxel2 or brm2 exhibit transformation of third leg to second leg identity and haltere to wing transformation.

ash11/ash114 females show a reversible block in oogenesis at 27oC: an increasing number of stage 14 egg chambers is evident per ovary with increasing temperature.

50% penetrance of the posterior wing to anterior wing transformation.

The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is increased in flies also containing a copy of ash11.

Lethality acts at the prepupal/pupal interface.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference

ash11 has visible | homeotic phenotype, non-suppressible by Df(2R)ED3921

Other
Statement
Reference
Phenotype Manifest In
NOT suppressed by
Statement
Reference

ash11 has haltere phenotype, non-suppressible by Df(2R)ED3921

ash11 has wing | ectopic phenotype, non-suppressible by Df(2R)ED3921

Enhancer of
Suppressor of
Statement
Reference

ash11 is a suppressor of wing phenotype of Scer\GAL4OK386, nejUAS.cMa

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Df(2R)ED3921 fails to suppress the haltere to wing transformation of ash11 flies.

Heterozygotes of ash11, ash16, and ash128 with brm2 have homeotic transformations of the third to the second leg. The expressivity of the transformed leg is variable, some have only a second leg apical bristle while others have a second leg preapical bristle as well. There is a lower penetrance of third leg transformations among flies heterozygous for ash11, ash16, and ash128 with brm5. Degree of penetrance corresponds to the severity of the ash1 allele (ash11 < ash16 < ash128). There is a lower penetrance of partial homeotic transformation of the haltere to the wing, or dorsal metathoracic cuticle to mesothoracic cuticle, and an even lower penetrance of first leg to second leg transformations.

Flies heterozygous for both Df(3R)red-P93 and ash11 express a weak transformation of halteres to wings or third legs to second legs.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Range of lethality for transheterozygotes extends from the third larval instar for the most severe alleles to the pharate adult stage for the least severe alleles.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
III-10
ash-1III-10
ash11
l(3)SG29a1
Name Synonyms
Secondary FlyBase IDs
    References (9)