FlyBase Allele Report: Dmel\brm[6]

General Information

Symbol

Dmel\brm⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0001300

Feature type

allele

Associated gene

Dmel\brm

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Brizuela et al., 1994, Kennison and Tamkun, 1988)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

ash1²⁸/ash1[+], brm⁶ has visible | homeotic phenotype

(Tripoulas et al., 1994)

ash1[+]/ash1¹, brm⁶ has visible | homeotic phenotype

(Tripoulas et al., 1994)

ash1[+]/ash1⁶, brm⁶ has visible | homeotic phenotype

(Tripoulas et al., 1994)

Phenotype Manifest In

Suppressor of

Statement

Reference

brm⁶ is a suppressor of phenotype of Pc⁴

(Kennison and Tamkun, 1988)

Other

Statement

Reference

ash1[+]/ash1¹, brm⁶ has scutellum phenotype

(Tripoulas et al., 1994)

ash1[+]/ash1¹, brm⁶ has metathoracic leg phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm⁶ has scutellum phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm⁶ has metathoracic leg phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm⁶ has haltere phenotype

(Tripoulas et al., 1994)

ash1²⁸/ash1[+], brm⁶ has prothoracic leg phenotype

(Tripoulas et al., 1994)

ash1[+]/ash1¹, brm⁶ has haltere phenotype

(Tripoulas et al., 1994)

ash1[+]/ash1¹, brm⁶ has prothoracic leg phenotype

(Tripoulas et al., 1994)

ash1[+]/ash1⁶, brm⁶ has scutellum phenotype

(Tripoulas et al., 1994)

ash1[+]/ash1⁶, brm⁶ has metathoracic leg phenotype

(Tripoulas et al., 1994)

ash1[+]/ash1⁶, brm⁶ has haltere phenotype

(Tripoulas et al., 1994)

ash1[+]/ash1⁶, brm⁶ has prothoracic leg phenotype

(Tripoulas et al., 1994)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygotes of ash1¹, ash1⁶, and ash1²⁸ with brm⁵ have homeotic transformations of the third to the second leg though with lower penetrance than flies heterozygous for ash1¹, ash1⁶, and ash1²⁸ with brm². Degree of penetrance corresponds to the severity of the ash1 allele (ash1¹ < ash1⁶ < ash1²⁸). There is a lower penetrance of partial homeotic transformation of the haltere to the wing, or dorsal metathoracic cuticle to mesothoracic cuticle, and an even lower penetrance of first leg to second leg transformations.

(Tripoulas et al., 1994)

Suppresses the extra sex comb phenotype of Pc⁴, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype.

(Kennison and Tamkun, 1988)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

brm⁶

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close