FlyBase Allele Report: Dmel\Nsf2[urd-2]

General Information

Symbol

Dmel\Nsf2^urd-2

Species

D. melanogaster

Name

FlyBase ID

FBal0017642

Feature type

allele

Associated gene

Dmel\Nsf2

Associated Insertion(s)

Carried in Construct

Also Known As

urd²

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

ethyl methanesulfonate

(Lindsley and Zimm, 1992, Kennison and Tamkun, 1988)

Progenitor genotype

Cytology

Description

Contains a G-to-A transition that affects the splice donor site of the second exon of Nsf2.

(Song et al., 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:13,837,377..13,837,377 [-]

Nucleotide change:

G13837377A

Reported nucleotide change:

G?A

Comment:

G to A mutation in splice donor site.

(Song et al., 2013)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(3R)BSC611)

(Kennison, 2012.9.27)

lethal (with Nsf2^A6)

(Kennison, 2012.9.27)

lethal (with Nsf2^A15)

(Kennison, 2012.9.27)

lethal | recessive

(Kennison and Tamkun, 1988)

lethal - all die before end of larval stage

(Lindsley and Zimm, 1992)

some die during larval stage

(Lindsley and Zimm, 1992)

Phenotype Manifest In

Detailed Description

Statement

Reference

urd² is lethal in combination with Df(3R)BSC611, but viable combined with Df(3R)BSC616.

(Kennison, 2012.9.27)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Nsf2^urd-2/Nsf2[+] is an enhancer of visible | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

NOT Enhancer of

Statement

Reference

Nsf2^urd-2 is a non-enhancer of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Suppressor of

Statement

Reference

Nsf2^urd-2/urd[+] is a suppressor of visible phenotype of Antp^Scx, Pc²¹

(Kennison and Tamkun, 1988)

NOT Suppressor of

Statement

Reference

Nsf2^urd-2 is a non-suppressor of visible phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Nsf2^urd-2 is a non-suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Nsf2^urd-2/Nsf2[+] is an enhancer of eye phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Feuillette et al., 2020)

Nsf2^urd-2/urd[+] is an enhancer of adult abdominal segment 4 | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

Nsf2^urd-2/urd[+] is an enhancer of adult abdominal segment 5 phenotype of E(z)^Trm

(Bajusz et al., 2001)

NOT Enhancer of

Statement

Reference

Nsf2^urd-2 is a non-enhancer of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Suppressor of

Statement

Reference

Nsf2^urd-2 is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Nsf2^urd-2/urd[+] is a suppressor of adult mesothoracic segment | ectopic phenotype of E(z)^Trm

(Bajusz et al., 2001)

Nsf2^urd-2/urd[+] is a suppressor of adult metathoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

Nsf2^urd-2/urd[+] is a suppressor of adult prothoracic segment phenotype of E(z)^Trm

(Bajusz et al., 2001)

Nsf2^urd-2/urd[+] is a suppressor of sex comb phenotype of Antp^Scx, Pc²¹

(Kennison and Tamkun, 1988)

Nsf2^urd-2 is a suppressor of phenotype of Pc⁴

(Kennison and Tamkun, 1988)

NOT Suppressor of

Statement

Reference

Nsf2^urd-2 is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, brm^{K804R.UAS.Tag:HA}

(Armstrong et al., 2005)

Other

Statement

Reference

Kr^If-1, Nsf2^urd-2/urd[+] has eye phenotype

(Sollars et al., 2003)

Kr^If-1, Nsf2^urd-2 has eye phenotype

(Sollars et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

5+/-2% of Kr^If-1/+ flies born to urd²/+ mothers have outgrowths with ectopic vibrissae protruding from the ventral region of the eye, compared to less than 0.1% of Kr^If-1/+ flies born to isogenised wild-type mothers.

(Sollars et al., 2003)

Mutant weakly suppresses the CycE^JP rough eye phenotype.

(Brumby et al., 2002)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is not suppressed by urd².

(Maixner et al., 1998)

Suppresses the extra sex comb phenotype of Pc²¹, Antp^Scx/+. Causes between 50% and 100% suppression of the Pc⁴/+ extra sex combs phenotype.

(Kennison and Tamkun, 1988)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Nsf2^A15

(Kennison, 2012.9.27)

Nsf2^A6

(Kennison, 2012.9.27)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5049

Nsf2^urd-2/TM3, Sb¹

Kyoto

108009

Nsf2^urd-2/TM6C, cu¹ Sb¹ ca¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Nsf2^urd-2

(Yamakawa et al., 2018)

urd²

(Vasanthi et al., 2013, Kennison, 2012.9.27, Vázquez et al., 2008, Chang et al., 2007)

urdur²

(Song et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (24)

Report Sections

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