The light dependent retinal degeneration seen in w1118 flies does not depend on sdtK85/+. The rate of photoreceptor cell survival seen in a w1118 genetic background is similar in sdtK85/+ or +/+ flies.
Expression of sdtScer\UAS.H.T:Zzzz\FLAG in outer photoreceptor cells under the control of Scer\GAL4ninaE.PT in sdtK85/+ or +/+ genetic background completely blocked the light induced retinal degeneration in w1118 flies. In addition, the rhabdomeres of the outer Scer\GAL4ninaE.PT-expressing photoreceptor cells are reduced in size in comparison with control flies and flies including flies kept in the dark.
Expression of sdtScer\UAS.D.T:Zzzz\FLAG under the control of Scer\GAL4ninaE.PT enhances the retinal degeneration phenotype in w1118 eyes. When sdtScer\UAS.D.T:Zzzz\FLAG is expressed in a sdtK85/+ background, the decrease in photoreceptor cell survival is stronger.
Flies carrying one copy of either wcad.PRE, wprod.PRE, weya.PRE or waPKC.PRE in a w1118/w1118; ph-p410/+ double mutant background have darker eyes than flies with one copy of wcad.PRE, wprod.PRE, weya.PRE or waPKC.PRE in a single mutant w1118/w1118 background.
Flies with a w1118/we(g) mutant genotype enhance the eye colour defective phenotype of g2, g50e and g53d homozygous mutants leading to a greater reduction of red pigment in the eye. w1118, g50e double mutant flies do not show the increased male-male courtship behaviour that single g50e mutants exhibit.
nahar38, w1118 mutant flies show the same sensitivity to 0.1% enflurane or halothane when tested under red light as nahar38 mutant flies do. However, nahar38, w1118 mutant flies show a much higher sensitivity to 0.05% enflurane or halothane when tested under ambient light than nahar38 mutant flies do.
The reduced sexual discrimination of w1118 males in the dark (they show similar courtship levels towards decapitated males and decapitated females) is rescued by Dp(1;Y)w+y+, but is not rescued by w+mC.
In daylight, w1118 males rescued by Dp(1;Y)w+y+ show a clear courtship preference for decapitated females over decapitated males, with the level of courtship towards decapitated males under these conditions being comparable to that seen in Oregon-R males.
In daylight, w1118 males rescued by w+mC show a clear courtship preference for decapitated females over decapitated males, although the level of courtship towards decapitated males shown by the rescued males is higher than the level seen in Oregon-R males under these conditions.