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General Information
Symbol
Dmel\hhunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0064870
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Stage 15 hhunspecified embryos have only ~13 genital disc precursor cells, instead of the wild-type number of 22.

Some mild defects in germ cell migration are seen in hhunspecified/+ embryos: fewer than 20% of the stage 13 to 16 embryos have four or more mispositioned germ cells(n=25).

hhMrt/+ embryos have defects in germ cell migration: and about 60% of the stage 13 to 16 embryos have four or more mispositioned germ cells (n=25). These defects are more severe in hhMrt/hhunspecified embryos: >90% of stage 13 to 16 have ten or more mispositioned germ cells (n = 20).

Mutants show dramatic increase in the number of midline glial cells. By the end of embryogenesis most of the midline glial cells are missing. Midline neurons are reduced in number. Commissure formation is delayed. In stage 13 only a few commissural axons have crossed the midline. In stage 16 embryos, commissures have formed but are reduced in size.

Formation of the visceral mesoderm is normal in homozygous embryos, and the visceral mesoderm migrates to cover the gut and form midgut constrictions.

Embryos show a germ cell migration defect and a significant reduction in the number of gonadal mesodermal cells.

The posterior naked section of the ventral part of each segment is deleted in hhunspecified mutant embryos and is replaced by a mirror image duplication of the anterior denticle belts. Segment boundaries appear to be missing.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Enhancer of
Statement
Reference
NOT Suppressor of
Statement
Reference

hhunspecified is a non-suppressor of phenotype of arm3

Additional Comments
Genetic Interactions
Statement
Reference

The mild germ cell migration defects seen in hhunspecified/+ embryos are strongly enhanced by dispunspecified/+: nearly 90% of stage 13 to 16 embryos have ten or more mispositioned germ cells (n = 20).

The mild germ cell migration defects seen in Hmgcrunspecified/+ embryos are enhanced by hhunspecified/+.

Enhances the lethality of Dfd13/Dfd3 flies grown at 29oC - leaving nearly zero survivors.

Xenogenetic Interactions
Statement
Reference

Expression of Zzzz\EFScer\UAS.cGa under the control of Scer\GAL4dpp.blk1 in a hhunspecified background significantly enhances the Zzzz\EFScer\UAS.cGa phenotype.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

7 mutants are isolated.

Four alleles isolated in this screen.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
hhunspecified
Name Synonyms
Secondary FlyBase IDs
    References (14)