FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hmgcrunspecified
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General Information
Symbol
Dmel\Hmgcrunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0086686
Feature type
allele
Associated gene
Dmel\Hmgcr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        There are minor germ cell migration defects in Hmgcrunspecified/+ embryos: about 35% of stage 13 to 16 embryos have four or more mispositioned germ cells

        (Deshpande and Schedl, 2005)

        Flies carrying small clones of Hmgcrunspecified homozygous cells are normal, but those large clones die as pupae with major patterning defects.

        (Santos and Lehmann, 2004)

        Many germ cells remain associated with the basal surface of the gut, instead of moving into lateral mesoderm. Those germ cells that do leave the PMG often appear disorganised within the mesoderm and do not correctly navigate toward the somatic gonadal precursors (SGPs). There is always a small number of germ cells in each mutant that are able to associate correctly with SGPs.

        (Moore et al., 1998)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The mild germ cell migration defects seen in Hmgcrunspecified/+ embryos are enhanced by hhunspecified/+ (>95% of stage 13 to 16 embryos have ten or more mispositioned germ cells (n = 20) and by dispunspecified/+.

        (Deshpande and Schedl, 2005)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        15 mutants are isolated.

        (Moore et al., 1998)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Hmgcrunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (4)