FlyBase Allele Report: Dmel\oro[1]

General Information

Symbol

Dmel\oro¹

Species

D. melanogaster

Name

FlyBase ID

FBal0060967

Feature type

allele

Associated gene

oro

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

diepoxybutane

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Epps et al., 1997)

Mutagen

diepoxybutane

(Epps et al., 1997, Tanda et al., 1996)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Epps et al., 1997)

lethal - all die during embryonic stage | recessive

(Tanda et al., 1996)

some die during embryonic stage | recessive

(Tanda et al., 1996)

Phenotype Manifest In

egg

(Epps et al., 1997)

embryonic/first instar larval cuticle

(Epps et al., 1997)

Detailed Description

Statement

Reference

Approximately 50% of homozygous embryos have an abnormal cuticle pattern, with 10-15% of these embryos having a wg- or hh-like cuticle pattern. Homozygous germ line clones are difficult to obtain in females and the rare eggs produced are more spherical than wild-type.

(Epps et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

oro¹ has lethal phenotype, suppressible by ptc⁹

(Tanda et al., 1996)

Other

Statement

Reference

oro¹, ptc⁹ has viable phenotype

(Epps et al., 1997)

Phenotype Manifest In

Enhancer of

Statement

Reference

oro¹/oro[+] is an enhancer of eye phenotype of hh^bar3

(Epps et al., 1997)

oro¹/oro[+] is an enhancer of ommatidium phenotype of hh^bar3

(Epps et al., 1997)

oro¹/oro[+] is an enhancer of eye phenotype of Bar¹

(Epps et al., 1997)

oro¹ is an enhancer of wing vein L3 phenotype of fu¹

(Epps et al., 1997)

oro¹ is an enhancer of wing vein L4 phenotype of fu¹

(Epps et al., 1997)

oro¹ is an enhancer of lateral ocellus phenotype of fu¹

(Epps et al., 1997)

oro¹ is an enhancer of phenotype of Bar^unspecified

(Tanda et al., 1996)

oro¹ is an enhancer of phenotype of wg¹

(Tanda et al., 1996)

oro¹ is an enhancer of phenotype of hh^unspecified

(Tanda et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Dominant enhancer of the B¹ and hh^bar3 eye phenotypes. ptc⁹ oro¹ double homozygous embryos have the same phenotype as ptc⁹ single mutant embryos, indicating that ptc is epistatic to oro. 96% of oro¹ ptc⁹/oro¹ + flies are viable. 46% of oro¹ ptc⁹/Df(2L)al flies are viable. The eyes of ptc⁹/+ ; hh^bar3/hh^bar3 and ptc⁹/oro¹; hh^bar3/hh^bar3 flies are similar in size, suggesting that ptc is epistatic to oro with respect to effects on hh^bar3. Dominantly enhances the fu¹ wing and ocellus phenotypes.

(Epps et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

oro²

(Epps et al., 1997)

Comments

Not an allele of smo.

(Tanda et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Isolated in a screen for mutations affecting morphogenetic furrow progression during early eye development. oro¹ is a stronger enhancer of the B¹ eye phenotype than oro². Germ line clonal analysis indicates that there is no significant maternal contribution to the embryonic lethal phenotype of oro¹.

(Epps et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

E(B)2A¹

(Tanda et al., 1996)

oro¹

Name Synonyms

Secondary FlyBase IDs

FBal0044762

References (3)

Report Sections

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