FlyBase Allele Report: Dmel\wg[1]

(Harris et al., 2016, Simón et al., 2014, Takacs et al., 2008, Sato et al., 1999, Emerald and Roy, 1997, Neumann and Cohen, 1996, Ng et al., 1996, van den Heuvel et al., 1993, Baker, 1987, Sharma and Shekaran, 1983, Sharma, 1973)

wing (with wg^17en40cP1)

(Wu and Cohen, 2002)

wing (with wg^l-17)

(Lee et al., 2009, Wang et al., 2000)

wing | conditional

(Harris et al., 2016)

wing disc (with wg^17en40cP1)

(Wu and Cohen, 2002)

wing disc | third instar larval stage

(Harris et al., 2016)

Detailed Description

Statement

Reference

wg¹/wg^l-17 and wg¹/wg^GBM, but not wg¹/+, larvae have significantly reduced bouton number and significantly increased bouton size at the neuromuscular junction of muscle 4, compared to controls.

(Huang et al., 2018)

In a significant proportion of wg¹ homozygotes, adults show transformation of one or both wings into notum and third instar larvae present wing discs with presumptive wing tissue replaced by notum tissue; these adults also present decreased wing regeneration capacity, as shown by the significant decrease in the number of adults with fully regenerated wings following rpr-induced damage to the third instar wing disc pouch, as compared to wild-type controls.

(Harris et al., 2016)

A minority of wg¹/+ flies have at least one wing transformed into notum.

(Simón et al., 2014)

wg¹/wg^l-12 flies show loss of indirect flight muscles.

(Benchabane et al., 2011)

wg¹/wg^l-17 mutants display a wing-to-notum transformation.

(Lee et al., 2009)

Homozygous wg¹ larvae do not show the increase in ghost bouton formation seen in controls upon spaced 5X K[+] depolarisation.

(Ataman et al., 2008)

Homozygotes show a wing to notum transformation.

(Takacs et al., 2008)

wg¹/wg^17en40cP1 wing discs show replacement of wing by a duplication of notum structures, which is also seen in the adult flies.

(Wu and Cohen, 2002)

wg¹/wg^l-17 flies exhibit ectopic notum and have no wings.

(Wang et al., 2000)

25% of wg¹/wg^P flies have wings on the prothoracic segment, and mesothoracic wings and metathoracic halteres develop variably.

(Emerald and Roy, 1997)

wg wing phenotype. Individuals are adult viable and exhibit the wing phenotype when in combination with wg^Sp-revP, wg^l-17, wg^l-16 or wg^P. Individuals are wild type when in combination with wg^Sp-1 and wg^spd-j2.

(Neumann and Cohen, 1996)

Flies often lack wings and show a symmetric duplication of body wall structures.

(Ng et al., 1996)

Semiviable, deletion of the ventralmost part of the eye. Ectopic furrow movement initiates predominantly from the ventral margin.

(Treisman and Rubin, 1995)

N, wg¹ and arm⁴ triple mutants display, with about 10-20% penetrance, a perfect duplication of the notum charcateristic of wg mutations.

(Couso and Martinez Arias, 1994)

Additional bristles present on the second leg.

(Held, 1993)

Flies exhibit a variable loss of one or two wings.

(van den Heuvel et al., 1993)

Adult homeotic transformation of wing to notum.

(Baker, 1987)

Phenotype shows incomplete penetrance and expressivity; 50.8% of flies have no wings, 40.67% have one wing, and 8.47% have two wings.

(Sharma and Shekaran, 1983)

The progeny of wg¹ parents are composed of flies with no wings, one wing and two wings in approximately 2:2:1 ratio. wg¹ flies may also have no, one, or both halteres. The two phenotypes are independent of each other as mutants can be found that have wings but no halteres, and vice versa.

(Sharma, 1973)

viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

wg¹ has visible | adult stage | dominant phenotype, enhanceable by p53[+]/p53^-ns

(Simón et al., 2014)

wg¹ has visible | adult stage | dominant phenotype, enhanceable by p53[+]/p53^11-1B-1

(Simón et al., 2014)

wg¹ has visible | adult stage | dominant phenotype, enhanceable by p53^5A-1-4/p53[+]

(Simón et al., 2014)

wg¹ has visible | recessive phenotype, enhanceable by ap^78j

(Sato et al., 1999)

NOT Enhanced by

Statement

Reference

wg¹ has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

wg¹/wg^GBM has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

Suppressed by

Statement

Reference

wg¹/wg^l-17 has visible phenotype, suppressible by Hipk^UAS.Tag:HA/Scer\GAL4^69B

(Lee et al., 2009)

wg¹/wg^l-17 has visible phenotype, suppressible by fz3^G10

(Sato et al., 1999)

NOT suppressed by

Statement

Reference

wg¹/wg^GBM has abnormal neuroanatomy | larval stage phenotype, non-suppressible by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

wg¹ has abnormal neuroanatomy | larval stage phenotype, non-suppressible by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

NOT Enhancer of

Statement

Reference

wg¹ is a non-enhancer of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Suppressor of

Statement

Reference

wg¹/wg[+] is a suppressor | partially of visible | adult stage phenotype of CtBP^87De-10, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa

(Worley et al., 2018)

wg¹/wg[+] is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

wg¹/fz3^G10 is a suppressor of visible | dominant phenotype of ap^78j

(Sato et al., 1999)

NOT Suppressor of

Statement

Reference

wg¹ is a non-suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

egh[+]/egh^62d18, wg¹ has abnormal neuroanatomy | larval stage phenotype

(Huang et al., 2018)

ap^78j, fz3^G10, wg¹ has visible | recessive phenotype

(Sato et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

wg¹ has wing phenotype, enhanceable by p53[+]/p53^-ns

(Simón et al., 2014)

wg¹ has wing phenotype, enhanceable by p53[+]/p53^11-1B-1

(Simón et al., 2014)

wg¹ has wing phenotype, enhanceable by p53^5A-1-4/p53[+]

(Simón et al., 2014)

wg¹ has wing phenotype, enhanceable by ap^78j

(Sato et al., 1999)

wg¹ has phenotype, enhanceable by oro¹

(Tanda et al., 1996)

NOT Enhanced by

Statement

Reference

wg¹ has embryonic/larval neuromuscular junction phenotype, non-enhanceable by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

wg¹ has terminal bouton | larval stage phenotype, non-enhanceable by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

wg¹/wg^GBM has embryonic/larval neuromuscular junction phenotype, non-enhanceable by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

wg¹/wg^GBM has terminal bouton | larval stage phenotype, non-enhanceable by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

Suppressed by

Statement

Reference

wg¹/wg^l-17 has wing phenotype, suppressible by Hipk^UAS.Tag:HA/Scer\GAL4^69B

(Lee et al., 2009)

wg¹/wg^l-17 has mesonotum | ectopic phenotype, suppressible by Hipk^UAS.Tag:HA/Scer\GAL4^69B

(Lee et al., 2009)

wg¹/wg^l-17 has wing phenotype, suppressible by fz3^G10

(Sato et al., 1999)

NOT suppressed by

Statement

Reference

wg¹/wg^GBM has embryonic/larval neuromuscular junction phenotype, non-suppressible by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

wg¹/wg^GBM has terminal bouton | larval stage phenotype, non-suppressible by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

wg¹ has embryonic/larval neuromuscular junction phenotype, non-suppressible by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

wg¹ has terminal bouton | larval stage phenotype, non-suppressible by egh^UAS.Tag:MYC/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

NOT Enhancer of

Statement

Reference

wg¹ is a non-enhancer of interommatidial bristle | pupal stage phenotype of ex^MGH1

(Pellock et al., 2007)

wg¹ is a non-enhancer of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Suppressor of

Statement

Reference

wg¹/wg[+] is a suppressor | partially of wing | ectopic phenotype of CtBP^87De-10, Scer\GAL4^rn-GAL4-5, egr^UAS.cUa

(Worley et al., 2018)

wg¹ is a suppressor | partially of eye | somatic clone phenotype of ex^MGH1

(Pellock et al., 2007)

wg¹ is a suppressor | partially of eye disc | pupal stage phenotype of ex^MGH1

(Pellock et al., 2007)

wg¹ is a suppressor of eye | ventral phenotype of L²

(Singh et al., 2006)

wg¹ is a suppressor of eye disc | ventral phenotype of L²

(Singh et al., 2006)

wg¹/fz3^G10 is a suppressor of wing phenotype of ap^78j

(Sato et al., 1999)

wg¹ is a suppressor of pigment cell phenotype of sgl⁰⁵⁰⁰⁷, w^a

(Benevolenskaya et al., 1998)

NOT Suppressor of

Statement

Reference

wg¹ is a non-suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

egh[+]/egh^62d18, wg¹ has embryonic/larval neuromuscular junction phenotype

(Huang et al., 2018)

egh[+]/egh^62d18, wg¹ has terminal bouton | larval stage phenotype

(Huang et al., 2018)

ap^78j, fz3^G10, wg¹ has wing phenotype

(Sato et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

wg¹/+; egh^62d18/+ double heterozygotes have significantly reduced bouton number and significantly increased bouton size at the neuromuscular junction of muscle 4, compared to controls, unlike either heterozygote alone.

(Huang et al., 2018)

Expression of egr^UAS.cUa under the control of Scer\GAL4^rn-GAL4-5 (with tub-Gal80[ts] restricting expression to third instar larvae) in wg¹/+ background does not lead to ectopic wings compared to controls.

(Worley et al., 2018)

Expression of hipk^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^69B in a wg¹/wg^l-17 mutant background results in proper wing development and rescues the wing-to-notum transformation.

(Lee et al., 2009)

The small eye phenotype of eyes composed almost entirely of ex^MGH1 mutant tissue is suppressed by the presence of wg¹.

The irregular ommatidial patterning of ex^MGH1 mutant pupal eye disc tissue is suppressed by wg¹. No additional supernumerary interommatidial cells are observed.

(Pellock et al., 2007)

The loss-of-ventral eye phenotype of L²/+ mutants is restored in L², wg¹/+ double mutants. Ommatidia in the restored ventral section show correct ventral eye polarity.

(Singh et al., 2006)

The wingless phenotype of wg¹/wg^l-17 flies is partially rescued by fz3^G10; the fraction of flies with two wings increases from 46% to 87%, while the fraction of one wing and wingless flies reduces from 44% and 10% to 13% and 0.5% respectively. The wingless phenotype of wg¹ homozygotes is dominantly enhanced by ap^78j; no wing blade is formed at approximately 90% of presumptive wing-blade-forming sites. This phenotype is partially suppressed by fz3^G10.

(Sato et al., 1999)

Xenogenetic Interactions

Statement

Reference

wg¹/+ significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU.

(Dupont et al., 2012)

Complementation and Rescue Data

Fails to complement

wg^NE1

(Dierick and Bejsovec, 1998)

wg^NE2

(Dierick and Bejsovec, 1998)

wg^PE6

(Dierick and Bejsovec, 1998)

Rescued by

wg¹/wg^GBM is rescued by wg^{UAS.cHa.Tag:HA}/Scer\GAL4^nSyb.PS

(Huang et al., 2018)

Comments

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

2978

wg¹ cn¹

3498

ap^ts78j wg¹/SM5

Kyoto

107069

ap^ts78j wg¹/SM5

107503

wg¹ cn¹ bw¹ speck¹/CyO, pr¹ cn² bw¹

Notes on Origin

Discoverer

Sharma.

Comments

A genotypically wg¹ mutant hemithorax is usually also phenotypically mutant in gynandromorphs; thus wg¹ is disc-autonomous.

(Babu and Bhat, 1986)

Pairwise complementation analysis of wg¹, wg^l-8, wg^H and an allele of spd reveals a complex complementation pattern.

(Tiong and Nash, 1990)

wg function during second larval instar affected.

(Couso and Martinez Arias, 1994)

FlyBase curator comment: the wg¹ mutation is reported as being caused by ethyl methanesulfonate in this reference but in FBrf0096285, a reference by the same author in the same issue of D.I. S., the mutation is reported as being X-ray-induced.

(Sharma, 1973)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Name Synonyms

Secondary FlyBase IDs

References (51)

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