Co-expression of hipkScer\UAS.T:Ivir\HA1 and ykiScer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 under the control of Scer\GAL4hh-Gal4 enhances the wing disc overgrowth seen when either construct is expressed alone.
Expression of hipkScer\UAS.T:Ivir\HA1 suppresses the overgrowth seen when ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 is expressed under the control of Scer\GAL4ptc-559.1. The phenotype is rescued in all tissues examined, including the wing disc and the eye. Fewer ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 expressing cells are seen, indicating that cell proliferation has been reduced.
Individuals co-expressing BacA\p35UAS.cHa and HipkUAS.Tag:HA under the control of Scer\GAL4dpp.blk1 arrest at the third larval stage for an extended period of time (beyond 10 days) and eventually die as larvae. BacA\p35UAS.cHa co-expression enhances the wing disc tumorigenesis of the expression of HipkUAS.Tag:HA expression (the Dpp expression domain cells expand substantially and occupy almost the entire disc) and does not suppress the melanotic masses.