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General Information
Symbol
Dmel\Opa1HMS00349
Species
D. melanogaster
Name
FlyBase ID
FBal0248114
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Opa1 RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing Opa1HMS00349 under the control of Scer\GAL4Cg.PA leads to fragmented mitochondria in the third instar larval fat body (as assessed by MitoGFP).

Expression of Opa1HMS00349 leads to strong defects in mitochondrial fusion in the body wall cells of third instar larvae (with the Scer\GAL4Mef2.PU driver) as well as in the indirect flight muscles in adults (with the Scer\GAL4Mhc.PU driver) - the mitochondria are short and fragmented compared to controls.

Flies expressing Opa1HMS00349 under the control of Scer\GAL4GMR.PU do not exhibit any discernible eye phenotype, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Co-expression of Hsap\UCP2Scer\UAS.cFa and Opa1HMS00349 under the control of Scer\GAL4GMR.PU does not result in a rough eye phenotype.

The presence of opa1-likeHMS00349 strongly enhances the reduced adult eye size phenotype found in Scer\GAL4hs.2sev->Mmus\Gria1Lc.Scer\UAS flies.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Opa1HMS00349
opa1-likeHMS00349
Name Synonyms
Secondary FlyBase IDs
    References (8)