UAS regulatory sequences drive expression of a short inverted repeat.
Expressing DhprHMC05508 under the control of Scer\GAL4Cg.PA leads to defects in third instar larval fat body mitochondria, which can be enlarged, fragmented, clustered (assessed by MitoGFP) and/or with less cristae (assessed by TEM); although the Golgi apparatus (assessed by ManII) and peroxisomes (assessed by SKL-GFP) appear normal, ER seems larger (assessed by KDEL-GFP).
DhprG16D.UAS.Tag:HA enhances the larval fat body mitochondrial defects induced by Scer\GAL4Cg.PA>DhprHMC05508, instead of rescuing them.
Expressing DhprHMC05508 under the control of Scer\GAL4Mef2.PR results in decreased adult climbing ability, as well as progressive adult thorax muscle degeneration (i.e. disorganized fibers in some muscle fragments); muscle mitochondria exhibit progressively more severe defects, including increased/irregular size, cristae disorganization and loss.
DhprG16D.UAS.Tag:HA enhances the adult thorax muscle mitochondrial defects induced by Scer\GAL4Mef2.PR>DhprHMC05508, instead of rescuing them.
Expressing DhprHMC05508 under the control of Scer\GAL4ple.PF (together with Dicer-2 expression, for a more efficient RNAi) results in clustered and enlarged mitochondria in adult TH-positive neurons.
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, enhanceable by nanosHMS00785, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, enhanceable by PuHMC04085, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, enhanceable by Drp1UAS.cDa/nanosHMS00785, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, enhanceable by MarfJF01650, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, enhanceable by Opa1HMS00349, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, enhanceable by MarfUAS.6x.Tag:MYC, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, enhanceable by Drp1HMC03230, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Mef2.PR has abnormal locomotor behavior | adult stage phenotype, enhanceable by Pink1UAS.cCa, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Mef2.PR has abnormal locomotor behavior | adult stage phenotype, enhanceable by nanosHMS00785, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, non-enhanceable by HnJF02261, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, non-enhanceable by TrhnJF01863, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, non-enhanceable by pleJF01813, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, non-enhanceable by Drp1C643A.UAS.Tag:HA, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Mef2.PR has abnormal locomotor behavior | adult stage phenotype, non-enhanceable by parkUAS.Tag:V5, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, suppressible by parkUAS.Tag:V5, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, suppressible | partially by Pink1UAS.cCa, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Mef2.PR has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by Drp1UAS.cDa, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, suppressible by Drp1UAS.cDa, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, suppressible | partially by PuHMC04085/Drp1UAS.cDa, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Mef2.PR has abnormal size | adult stage phenotype, suppressible by Pink1UAS.cCa, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Mef2.PR has abnormal size | adult stage phenotype, suppressible by parkUAS.Tag:V5, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Mef2.PR has abnormal size | adult stage phenotype, suppressible by Drp1UAS.cDa, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Mef2.PR has abnormal locomotor behavior | adult stage phenotype, non-suppressible by parkUAS.Tag:V5, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, non-suppressible by HnJF02261, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, non-suppressible by TrhnJF01863, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, non-suppressible by pleJF01813, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has abnormal size | third instar larval stage phenotype, non-suppressible by Drp1C643A.UAS.Tag:HA, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA is an enhancer of abnormal size | third instar larval stage phenotype of MarfUAS.6x.Tag:MYC, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA is a non-enhancer of abnormal size | third instar larval stage phenotype of Drp1HMC03230, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA is a non-suppressor of abnormal size | third instar larval stage phenotype of Drp1HMC03230, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, enhanceable by nanosHMS00785, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, enhanceable by nanosHMS00785, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, enhanceable by PuHMC04085, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, enhanceable by PuHMC04085, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, enhanceable by Drp1UAS.cDa/nanosHMS00785, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, enhanceable by Drp1UAS.cDa/nanosHMS00785, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Mef2.PR has adult somatic muscle cell of thorax | adult stage | progressive phenotype, enhanceable by Pink1B9
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, enhanceable by MarfJF01650, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, enhanceable by MarfJF01650, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, enhanceable by Opa1HMS00349, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, enhanceable by Opa1HMS00349, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, enhanceable by MarfUAS.6x.Tag:MYC, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, enhanceable by MarfUAS.6x.Tag:MYC, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Mef2.PR has mitochondrion | adult stage | progressive phenotype, enhanceable by Pink1B9
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, enhanceable by Drp1HMC03230, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, enhanceable by Drp1HMC03230, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Mef2.PR has mitochondrial crista | adult stage | progressive phenotype, enhanceable by Pink1B9
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, non-enhanceable by HnJF02261, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, non-enhanceable by HnJF02261, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, non-enhanceable by TrhnJF01863, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, non-enhanceable by TrhnJF01863, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, non-enhanceable by pleJF01813, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, non-enhanceable by pleJF01813, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Mef2.PR has adult somatic muscle cell of thorax | adult stage phenotype, non-enhanceable by nanosHMS00785, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, suppressible by parkUAS.Tag:V5, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, suppressible by parkUAS.Tag:V5, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, suppressible | partially by Pink1UAS.cCa, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, suppressible | partially by Pink1UAS.cCa, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Mef2.PR has adult somatic muscle cell of thorax | adult stage | progressive phenotype, suppressible by Pink1UAS.cCa, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Mef2.PR has adult somatic muscle cell of thorax | adult stage | progressive phenotype, suppressible | partially by parkUAS.Tag:V5, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Mef2.PR has mitochondrion | adult stage | progressive phenotype, suppressible | partially by Pink1UAS.cCa, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Mef2.PR has mitochondrial crista | adult stage | progressive phenotype, suppressible | partially by Pink1UAS.cCa, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Mef2.PR has mitochondrial crista | adult stage | progressive phenotype, suppressible | partially by parkUAS.Tag:V5, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, suppressible by Drp1UAS.cDa, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, suppressible by Drp1UAS.cDa, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, suppressible | partially by Drp1C643A.UAS.Tag:HA, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, suppressible | partially by Drp1C643A.UAS.Tag:HA, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Mef2.PR has adult somatic muscle cell of thorax | adult stage phenotype, suppressible by Drp1UAS.cDa, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Mef2.PR has mitochondrion | adult stage phenotype, suppressible by Drp1UAS.cDa, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, suppressible | partially by PuHMC04085/Drp1UAS.cDa, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, suppressible | partially by PuHMC04085/Drp1UAS.cDa, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, non-suppressible by pleJF01813, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, non-suppressible by pleJF01813, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Mef2.PR has adult somatic muscle cell of thorax | adult stage phenotype, non-suppressible by nanosHMS00785, Scer\GAL4Mef2.PR
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, non-suppressible by HnJF02261, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, non-suppressible by HnJF02261, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has mitochondrion | third instar larval stage phenotype, non-suppressible by TrhnJF01863, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, non-suppressible by TrhnJF01863, Scer\GAL4Cg.PA
Scer\GAL4Mef2.PR/DhprHMC05508 is an enhancer of adult somatic muscle cell of thorax phenotype of Pink1B9
Scer\GAL4Mef2.PR/DhprHMC05508 is an enhancer of mitochondrion | adult stage phenotype of Pink1B9
Scer\GAL4Mef2.PR/DhprHMC05508 is an enhancer of mitochondrial crista | adult stage phenotype of Pink1B9
DhprHMC05508, Scer\GAL4Cg.PA is an enhancer of mitochondrion | third instar larval stage phenotype of MarfUAS.6x.Tag:MYC, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA is an enhancer of embryonic/larval fat body | third instar larval stage phenotype of MarfUAS.6x.Tag:MYC, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA is a non-enhancer of mitochondrion | third instar larval stage phenotype of Drp1HMC03230, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA is a non-enhancer of embryonic/larval fat body | third instar larval stage phenotype of Drp1HMC03230, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA is a non-suppressor of mitochondrion | third instar larval stage phenotype of Drp1HMC03230, Scer\GAL4Cg.PA
DhprHMC05508, Scer\GAL4Cg.PA is a non-suppressor of embryonic/larval fat body | third instar larval stage phenotype of Drp1HMC03230, Scer\GAL4Cg.PA
DhprHMC05508 is rescued by DhprUAS.Tag:HA/Scer\GAL4Cg.PA
DhprHMC05508 is rescued by DhprUAS.Tag:HA/Scer\GAL4Mef2.PR
DhprHMC05508 is not rescued by Scer\GAL4Cg.PA/DhprG16D.UAS.Tag:HA
DhprHMC05508 is not rescued by Scer\GAL4Mef2.PR/DhprG16D.UAS.Tag:HA