FlyBase Allele Report: Dmel\Marf[UAS.6x.Tag:MYC]

General Information

Symbol

Dmel\Marf^{UAS.6x.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0319509

Feature type

allele

Associated gene

Dmel\Marf

Associated Insertion(s)

Carried in Construct

P{UAS-Marf.6xMyc}

Also Known As

UAS-Marf-Myc

Key Links

Transgenic product class

cDNA

(Zhang et al., 2016)

wild_type

(Zhang et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Zhang et al., 2016)

wild_type

(Zhang et al., 2016)

Mutagen

in vitro construct

(Zhang et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-Marf.6xMyc}

Cytology

Description

UAS regulates expression of a Marf cDNA containing a C-terminal 6x Tag:MYC tag.

(Zhang et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Marf

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing Marf^{UAS.6x.Tag:MYC} under the control of Scer\GAL4^Cg.PA results in enlarged mitochondria (showing as large blobs) in the early third instar larval fat body.

(Liu et al., 2020)

Expressing Marf^{UAS.6x.Tag:MYC} under the control of Scer\GAL4^Cg.PA leads to enlarged mitochondrial in the third instar larval fat body (as assessed by MitoGFP).

(Zhou et al., 2019)

Over-expression of Marf^{Scer\UAS.6x.T:Hsap\MYC} driven by Scer\GAL4^Cg.PA results in clustering and elongation of mitochondria.

(Zhang et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PA has abnormal size | third instar larval stage phenotype, enhanceable by Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Enhancer of

Statement

Reference

Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PA is an enhancer of abnormal size | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Phenotype Manifest In

Enhanced by

Statement

Reference

Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PA has mitochondrion | third instar larval stage phenotype, enhanceable by Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PA has embryonic/larval fat body | third instar larval stage phenotype, enhanceable by Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Suppressed by

Statement

Reference

Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PU has fat body phenotype, suppressible by Trabd⁴/Trabd⁴

(Zhou et al., 2024)

Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PU has mitochondrion phenotype, suppressible by Trabd⁴/Trabd⁴

(Zhou et al., 2024)

Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PA has embryonic/larval fat body | early third instar larval stage phenotype, suppressible by Chchd2^8-8

(Liu et al., 2020)

Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PA has mitochondrion | early third instar larval stage phenotype, suppressible by Chchd2^8-8

(Liu et al., 2020)

Enhancer of

Statement

Reference

Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PA is an enhancer of mitochondrion | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PA is an enhancer of embryonic/larval fat body | third instar larval stage phenotype of Dhpr^HMC05508, Scer\GAL4^Cg.PA

(Zhou et al., 2019)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Cg.PA/Marf^{UAS.6x.Tag:MYC} is a non-suppressor of mitochondrion | somatic clone | adult stage phenotype of Miga^XKYF025

(Zhang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Miga^XKYF025/Miga^XKYF025 fat body clones still show mitochondrial fragmentation (swollen, round, lost cristae) with additional expression of Marf^{Scer\UAS.6x.T:Hsap\MYC} driven by Scer\GAL4^Cg.PA.

(Zhang et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Marf^{Scer\UAS.6x.T:Hsap\MYC}

Marf^{UAS.6x.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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