FlyBase Allele Report: Dmel\Trabd[4]

General Information

Symbol

Dmel\Trabd⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0404532

Feature type

allele

Associated gene

Dmel\Trabd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Zhou et al., 2024)

Mutagen

CRISPR/Cas9

(Zhou et al., 2024)

Progenitor genotype

Cytology

Description

Deletion of 2 bp in exon 2, resulting in the early termination of protein translation after 43 amino acids.

(Zhou et al., 2024)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:13,030,009..13,030,010 [-]

Comment:

Deletion of 2bp in Trabd starting in codon D14 results in a frameshift and early translation termination

(Zhou et al., 2024)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegenerative disease

CEA

(Zhou et al., 2024)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of adult locomotory behavior | progressive

(Zhou et al., 2024)

decreased size | larval stage

(Zhou et al., 2024)

Phenotype Manifest In

embryonic/larval fat body | larval stage

(Zhou et al., 2024)

flight muscle | adult stage

(Zhou et al., 2024)

mitochondrial crista | adult stage

(Zhou et al., 2024)

mitochondrion | adult stage

(Zhou et al., 2024)

mitochondrion | larval stage

(Zhou et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Trabd⁴/Trabd⁴ is an enhancer of mitochondrion phenotype of Marf^HMC03883, Scer\GAL4^Cg.PU

(Zhou et al., 2024)

Trabd⁴/Trabd⁴ is an enhancer of fat body phenotype of Marf^HMC03883, Scer\GAL4^Cg.PU

(Zhou et al., 2024)

Suppressor of

Statement

Reference

Trabd⁴/Trabd⁴ is a suppressor | partially of mitochondrion | larval stage phenotype of Drp1^HMC03230, Scer\GAL4^Cg.PU

(Zhou et al., 2024)

Trabd⁴/Trabd⁴ is a suppressor | partially of embryonic/larval fat body | larval stage phenotype of Drp1^HMC03230, Scer\GAL4^Cg.PU

(Zhou et al., 2024)

Trabd⁴/Trabd⁴ is a suppressor | partially of mitochondrial crista | larval stage phenotype of Drp1^HMC03230, Scer\GAL4^Cg.PU

(Zhou et al., 2024)

Trabd⁴/Trabd⁴ is a suppressor of fat body phenotype of Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PU

(Zhou et al., 2024)

Trabd⁴/Trabd⁴ is a suppressor of mitochondrion phenotype of Marf^{UAS.6x.Tag:MYC}, Scer\GAL4^Cg.PU

(Zhou et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Trabd⁴ is rescued by Trabd^Tag:V5

(Zhou et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Trabd⁴

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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