FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MigaXKYF025
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General Information
Symbol
Dmel\MigaXKYF025
Species
D. melanogaster
Name
FlyBase ID
FBal0319504
Feature type
allele
Associated gene
Dmel\Miga
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Zhang et al., 2016)
Progenitor genotype
Cytology
Description

Amino acid replacement: G34D.

(Zhang et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:8,436,186..8,436,186 [-]
Nucleotide change:

G8436186A

Reported nucleotide change:

G?A

Amino acid change:

G34D | Miga-PA; G34D | Miga-PB; G34D | Miga-PC

Reported amino acid change:

G34D

(Zhang et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      One day old flies with MigaXKYF025/MigaXKYF025 mutant photoreceptor clones (in otherwise heterozygous flies) show grossly normal retina morphology, but by 30 days old some rhabdomeres become irregularly shaped and some are lost (a significant decrease in the number rhabdomeres per ommatidium is seen compared to controls); inside photoreceptor cells of 30 day old mutants, some mitochondria become round and swollen and have abnormal cristae (a significant increase in the number of damaged mitochondria per ommatidium is seen compared to controls).

      MigaXKYF025/MigaXKYF025 fat body clones show mitochondrial fragmentation (swollen, round, lost cristae) compared to controls.

      (Zhang et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      MigaXKYF025/MigaXKYF025 fat body clones still show mitochondrial fragmentation (swollen, round, lost cristae) with additional expression of MarfScer\UAS.6x.T:Hsap\MYC driven by Scer\GAL4Cg.PA.

      Over-expression of Drp1HMC03230 driven by Scer\GAL4Cg.PA does not suppress mitochondrial fragmentation in MigaXKYF025/MigaXKYF025 fat body clones.

      Expression of zucScer\UAS.T:Ivir\HA1 driven by Scer\GAL4Cg.PA does not suppress mitochondrial fragmentation in MigaXKYF025/MigaXKYF025 fat body clones.

      Flies with expression of zucDN.Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4Cg.PA in MigaXKYF025/MigaXKYF025 clones have mitochondrial fragmentation in fat body cells.

      (Zhang et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      MigaXKYF025 is rescued by MigaTag:HA

      (Zhang et al., 2016)
      Comments

      MigaT:Ivir\HA1 rescues pupal lethality in MigaXKYF025/MigaXKYF025 mutants and rescues rhabdomere degeneration and mitochondrial defects in 30 day old MigaXKYF025/MigaXKYF025 flies (photoreceptor clones). MigaT:Ivir\HA1 rescues mitochondrial fragmentation in MigaXKYF025/MigaXKYF025 fat body clones.

      (Zhang et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MigaXKYF025
      XKYF025
      (Zhang et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)