FlyBase Allele Report: Dmel\Chchd3[HMC02376]

General Information

Symbol

Dmel\Chchd3^HMC02376

Species

D. melanogaster

Name

FlyBase ID

FBal0292107

Feature type

allele

Associated gene

Dmel\Chchd3

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC02376}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC02376}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC02376

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of hypoplastic left heart syndrome

CEA

(Birker et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of hypoplastic left heart syndrome

is exacerbated by Cdk12^GD9926

(Birker et al., 2023)

is exacerbated by Drp1^JF02762

(Birker et al., 2023)

is ameliorated by Drp1^UAS.cDa

(Birker et al., 2023)

is exacerbated by Opa1^HMS00349

(Birker et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

decreased rate of adult locomotory behavior, with Scer\GAL4^Mef2.PR

(Birker et al., 2023)

short lived, with Scer\GAL4^Mef2.PR

(Birker et al., 2023)

Phenotype Manifest In

adult heart, with Scer\GAL4^HCH.Hand

(Birker et al., 2023)

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

filamentous actin | adult stage, with Scer\GAL4^HCH.Hand

(Birker et al., 2023)

filamentous actin | adult stage, with Scer\GAL4^Mef2.PR

(Birker et al., 2023)

indirect flight muscle | adult stage, with Scer\GAL4^Mef2.PR

(Birker et al., 2023)

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

sarcomere | adult stage, with Scer\GAL4^Mef2.PR

(Birker et al., 2023)

Detailed Description

Statement

Reference

Expressing Chchd3^HMC02376 under the control of Scer\GAL4^Cg.PA leads to fragmented mitochondria in the third instar larval fat body (as assessed by MitoGFP).

(Zhou et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Chchd3^HMC02376, Scer\GAL4^HCH.Hand is an enhancer of increased mortality during development phenotype of Cdk12^GD9926, Scer\GAL4^HCH.Hand

(Birker et al., 2023)

Other

Statement

Reference

β-Spec^GD11790, Chchd3^HMC02376, Scer\GAL4^HCH.Hand has viable phenotype

(Birker et al., 2023)

Chchd3^HMC02376, Scer\GAL4^HCH.Hand, gol^GD3528 has viable phenotype

(Birker et al., 2023)

Phenotype Manifest In

Enhanced by

Statement

Reference

Chchd3^HMC02376, Scer\GAL4^HCH.Hand has filamentous actin | adult stage phenotype, enhanceable by Opa1^UAS.Tag:FLAG, Scer\GAL4^HCH.Hand

(Birker et al., 2023)

Chchd3^HMC02376, Scer\GAL4^HCH.Hand has adult heart phenotype, enhanceable by Opa1^UAS.Tag:FLAG, Scer\GAL4^HCH.Hand

(Birker et al., 2023)

Other

Statement

Reference

β-Spec^GD11790, Chchd3^HMC02376, Scer\GAL4^HCH.Hand has adult heart phenotype

(Birker et al., 2023)

β-Spec^GD11790, Chchd3^HMC02376, Scer\GAL4^HCH.Hand has filamentous actin | adult stage phenotype

(Birker et al., 2023)

Chchd3^HMC02376, Drp1^JF02762, Scer\GAL4^HCH.Hand has adult heart phenotype

(Birker et al., 2023)

Chchd3^HMC02376, Drp1^JF02762, Scer\GAL4^HCH.Hand has filamentous actin | adult stage phenotype

(Birker et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

51157

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02376}attP2

NIG-Fly

HMC02376

y¹ sc^* v¹ sev²¹; P{TRiP.HMC02376}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Chchd3^HMC02376

l(3)03670^HMC02376

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close