FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NUAS.cMa
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General Information
Symbol
Dmel\NUAS.cMa
Species
D. melanogaster
Name
FlyBase ID
FBal0138460
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-NFL, UAS-Notch, UAS-N, UAS-NotchFL, UAS-Nfull
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UAS sequences drive expression of full-length N.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of NUAS.cMa under the control of Scer\GAL4pnt-14-94 results in increased numbers of type II neuroblasts in the larval brain. These type II neuroblasts and their daughter mature intermediate precursor cells show clustered mitochondria to one side of the nucleus.

Expressing NUAS.cMa under the control of Scer\GAL4GMR.PU leads to a rough eye phenotype.

Expression of NScer\UAS.cMa under the control of Scer\GAL4tey-5053A has no effect on the number of tracheal branches that terminate on ventrolateral body wall muscle 12.

Expression of NScer\UAS.cMa under the control of Scer\GAL4elav.PH in clones induced by FLP/FRT mediated recombination (to activate the Scer\GAL4elav.PH driver) results in a decrease in the number of type 1b boutons at muscle 13 compared to wild type.

Expression of NScer\UAS.cMa during retina formation, under the control of Scer\GAL4GMR.PF, causes a rough eye phenotype.

Expression of NScer\UAS.cMa under the control of Scer\GAL4ptc-559.1 results in a loss of the anterior crossvein in the wing.

Expression of NScer\UAS.cMa under the control of Scer\GAL4ptc-559.1 at 25oC results in a weak ectopic wing margin phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
NOT Enhanced by
Suppressed by
NOT suppressed by
Statement
Reference
NOT Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Statement
Reference
Suppressed by
NOT suppressed by
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Expression of NScer\UAS.cMa under the control of Scer\GAL4bab1-Gal4 (limited to the adult stages using Scer\GAL80ts.αTub84B) does not suppress the germline stem cell and cap cell loss seen in InR339/InRE19.

Expression of NScer\UAS.cMa under the control of Scer\GAL4elav.PH in ewg2 motorneurons (these motorneurons have been obtained by using FLP/FRT mediated recombination to inactivate the ewgelav.PH rescuing transgene and simultaneously activate the Scer\GAL4elav.PH driver in a ewg2 background) results in intermediate numbers of boutons at the larval neuromuscular junction compared to wild-type and ewg2 motorneurons.

Expression of EP2124EP2124 does not enhance the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of EP417EP417 does not enhance the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of ballEP863 does not enhance the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of NFATEP1353 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of CG6961EP1607 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of EP1618EP1618 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of MESR4EP386 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of CamEP1027 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of Sema-2bEP2056 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of EP2081EP2081 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of EP2161EP2161 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of PinoEP2263 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of PinoEP2576 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of EP2522EP2522 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of JHDM2EP703 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of SNF4AγEP772 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of trxEP1105 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of EP902EP902 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of trxEP3541 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of muraEP1202 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of sdaEP3289 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of meltEP3377 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of hephEP3574 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of CG2003EP3574 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of E(spl)m7-HLHEP3587 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Expression of ssp2EP3685 does not suppress the rough eye phenotype seen when NScer\UAS.cMa is expressed under the control of Scer\GAL4GMR.PU.

Although animals heterozygous for auxI670K are normal, this background strongly reduces the eye size and enhances the rough eye of NScer\UAS.cMa;Scer\GAL4GMR.PF animals.

The wing phenotype seen in flies co-expressing Nedd4GS13178 and NScer\UAS.cMa under the control of Scer\GAL4ptc-559.1 resembles that seen in flies expressing Nedd4GS13178 alone under the control of Scer\GAL4ptc-559.1.

The ectopic wing phenotype caused by expression of NScer\UAS.cMa under the control of Scer\GAL4ptc-559.1 at 25oC is enhanced by co-expression of either Su(dx)Δ-HECT.Scer\UAS or Nedd4CA.Scer\UAS.T:Hsap\MYC.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of NScer\UAS.cMa under the control of Scer\GAL4tin.CΔ4 rescues the abnormal cardiac function of Df(2L)Exel7007 flies.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
NScer\UAS.cMa
NUAS.cMa
Name Synonyms
Secondary FlyBase IDs
    References (35)