FlyBase Allele Report: Dmel\NFAT[EP1353]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\NFAT^EP1353

General Information

Symbol

Dmel\NFAT^EP1353

Species

D. melanogaster

Name

FlyBase ID

FBal0120757

Feature type

allele

Associated gene

Associated Insertion(s)

P{EP}NFAT^EP1353

Carried in Construct

Also Known As

EP(X)1353, EP1353

Key Links

Genomic Maps

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Laurencon, 2001.7.23, Huang and Rubin, 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}NFAT^EP1353

Cytology

Description

The P{EP} element is inserted within the 5' UTR of the predicted mRNA.

(Kraut et al., 2001)

Allele components

Component

Use(s)

Inserted element

misexpression element

Regulatory region(s)

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:13,624,789..13,624,789 [+]

(Park and Song, 2008, Keyser et al., 2007, Singh et al., 2005, Zhu et al., 2005, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Laurencon, 2001.7.23, Huang and Rubin, 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

(Huang and Rubin, 2000)

Phenotype Manifest In

anterior fascicle & synapse, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

larval intersegmental nerve, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

Detailed Description

Statement

Reference

Mutant larvae expressing NFAT^EP1353 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses. Mutant larvae expressing NFAT^EP1353 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects.

(Kraut et al., 2001)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

NFAT^EP1353, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Cdc42^L89.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NFAT^EP1353/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

NFAT^EP1353/Scer\GAL4^hs.2sev is an enhancer of visible phenotype of ksr::tor^{ΔNksr.hs.sev}

(Huang and Rubin, 2000)

NOT Enhancer of

Statement

Reference

NFAT^EP1353, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NFAT^EP1353, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Suppressor of

Statement

Reference

NFAT^EP1353, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Scer\GAL4^GMR.PU, lok^UAS.cPb

(Park and Song, 2008)

NFAT^EP1353/Scer\GAL4^ey.PH is a suppressor of visible | dominant phenotype of L²

(Singh et al., 2005)

NFAT^EP1353, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

NFAT^EP1353, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Pvr^λ.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NFAT^EP1353/Scer\GAL4^hs.2sev is a suppressor of visible phenotype of Ras85D^V12.sev

(Huang and Rubin, 2000)

NOT Suppressor of

Statement

Reference

NFAT^EP1353, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of N^UAS.cMa, Scer\GAL4^GMR.PU

(Park and Song, 2008)

NFAT^EP1353, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NFAT^EP1353, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

NFAT^EP1353/Scer\GAL4^pnr-MD237 is an enhancer of chaeta phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

NFAT^EP1353/Scer\GAL4^hs.2sev is an enhancer of eye phenotype of ksr::tor^{ΔNksr.hs.sev}

(Huang and Rubin, 2000)

NOT Enhancer of

Statement

Reference

NFAT^EP1353, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Suppressor of

Statement

Reference

NFAT^EP1353, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, lok^UAS.cPb

(Park and Song, 2008)

NFAT^EP1353/Scer\GAL4^ey.PH is a suppressor of eye | ventral phenotype of L²

(Singh et al., 2005)

NFAT^EP1353, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

NFAT^EP1353, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Pvr^λ.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NFAT^EP1353/Scer\GAL4^hs.2sev is a suppressor of eye phenotype of Ras85D^V12.sev

(Huang and Rubin, 2000)

NOT Suppressor of

Statement

Reference

NFAT^EP1353, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of N^UAS.cMa, Scer\GAL4^GMR.PU

(Park and Song, 2008)

NFAT^EP1353, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Other

Statement

Reference

NFAT^EP1353, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has scutellar bristle phenotype

(Pena-Rangel et al., 2002)

NFAT^EP1353, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has microchaeta phenotype

(Pena-Rangel et al., 2002)

NFAT^EP1353, Scer\GAL4^pnr-MD237, pnr^MD237 has scutellar bristle phenotype

(Pena-Rangel et al., 2002)

NFAT^EP1353, Scer\GAL4^pnr-MD237, pnr^MD237 has microchaeta phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of NFAT^EP1353 suppresses the rough eye phenotype seen when lok^Scer\UAS.cPb is expressed under the control of Scer\GAL4^GMR.PU.

Expression of NFAT^EP1353 does not suppress the rough eye phenotype seen when N^Scer\UAS.cMa is expressed under the control of Scer\GAL4^GMR.PU.

(Park and Song, 2008)

pnr^MD237/+ adults expressing NFAT^EP1353 under the control of Scer\GAL4^pnr-MD237 show loss of microchaetae and deformed scutellar macrochaetae.

(Pena-Rangel et al., 2002)

Strong enhancer of ksr::tor^{ΔNksr.hs.sev} and moderate suppressor of Ras85D^V12.sev, when expression is driven by Scer\GAL4^hs.2sev.

(Huang and Rubin, 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

19579

w¹¹¹⁸ P{EP}NFAT^EP1353

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

Comments

Comments

Complements: mus106^D1.

(Laurencon, 2001.7.23)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

MESR1^EP1353

(Huang and Rubin, 2000)

NFAT^EP1353

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections