FlyBase Allele Report: Dmel\Mtx2[5'.sgRNA]

General Information

Symbol

Dmel\Mtx2^5'.sgRNA

Species

D. melanogaster

Name

FlyBase ID

FBal0407317

Feature type

allele

Associated gene

Dmel\Mtx2

Associated Insertion(s)

Carried in Construct

PBac{Mtx2-sgRNA.5'}

Key Links

Transgenic product class

sgRNA

(Zhang et al., 2025)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

sgRNA

(Zhang et al., 2025)

Mutagen

in vitro construct

(Zhang et al., 2025)

Progenitor genotype

Carried in construct

PBac{Mtx2-sgRNA.5'}

Cytology

Description

snRNA:U6:96Ac regulatory sequences drive expression of two sgRNAs targeting the 5' coding region of Mtx2 gene.

(Zhang et al., 2025)

Allele components

Component

Use(s)

Regulatory region(s)

snRNA:U6:96Ac

Encoded product / tool

Mtx2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

axon | adult stage, with Scer\GAL4^GMR15B07, Spyo\Cas9^UAS.P2

(Zhang et al., 2025)

gustatory receptor neuron of the wing, with Scer\GAL4^GMR15B07, Spyo\Cas9^UAS.P2

(Zhang et al., 2025)

mitochondrion | adult stage, with Scer\GAL4^GMR15B07, Spyo\Cas9^UAS.P2

(Zhang et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of mitochondrion | adult stage phenotype of Opa1^HMS00349, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of axon | adult stage phenotype of Opa1^HMS00349, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of gustatory receptor neuron of the wing phenotype of Opa1^RNAi.CDS.UAS, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of mitochondrion | adult stage phenotype of Opa1^RNAi.CDS.UAS, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of axon | adult stage phenotype of Opa1^RNAi.CDS.UAS, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of mitochondrion | adult stage phenotype of Opa1^UAS.Tag:FLAG, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of gustatory receptor neuron of the wing phenotype of Opa1^UAS.Tag:FLAG, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of axon | adult stage phenotype of Opa1^UAS.Tag:FLAG, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of mitochondrion | adult stage phenotype of Marf^UAS.Tag:FLAG, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of gustatory receptor neuron of the wing phenotype of Marf^UAS.Tag:FLAG, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of axon | adult stage phenotype of Marf^UAS.Tag:FLAG, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is an enhancer of gustatory receptor neuron of the wing phenotype of Opa1^HMS00349, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

NOT Enhancer of

Statement

Reference

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is a non-enhancer of gustatory receptor neuron of the wing phenotype of Marf^HMC03883, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is a non-enhancer of mitochondrion | adult stage phenotype of Marf^HMC03883, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is a non-enhancer of axon | adult stage phenotype of Marf^HMC03883, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is a non-enhancer of gustatory receptor neuron of the wing phenotype of Marf^{RNAi.CDS.UAS.cSa}, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is a non-enhancer of mitochondrion | adult stage phenotype of Marf^{RNAi.CDS.UAS.cSa}, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Mtx2^5'.sgRNA/Spyo\Cas9^UAS.P2, Scer\GAL4^GMR15B07 is a non-enhancer of axon | adult stage phenotype of Marf^{RNAi.CDS.UAS.cSa}, Scer\GAL4^GMR15B07

(Zhang et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Mtx2^5'.sgRNA

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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