FlyBase Allele Report: Dmel\N[ICN.UAS]

General Information

Symbol

Dmel\N^ICN.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0090559

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

P{UAS-N.ICN}

Also Known As

UAS-NICD, UAS-N^act, UAS-N^intra, UAS-N^ICD, UAS-Nⁱ, N^ACT, N^intra, uas-Nintra, UAS-Nic, UAS-Notch-ICD

Key Links

Transgenic product class

inframe_deletion

(Go et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Go et al., 1998)

Mutagen

in vitro construct

(Kurata et al., 2000, Go et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-N.ICN}

Cytology

Description

UAS regulatory sequences drive expression of a constitutively active form of N in which the extracellular domain including the signal peptide and transmembrane domain is deleted.

(Go et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA

(Wang et al., 2021, Harsh and Eleftherianos, 2020)

CEA with Mef2^UAS.cUa

(Harsh and Eleftherianos, 2020)

model of carcinoma

CEA with Mef2^UAS.cUa

(Pallavi et al., 2012)

CEA with egr^UAS.cUa

(Pallavi et al., 2012)

model of brain cancer

CEA

(Wang et al., 2006)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cancer

is ameliorated by CycE^HMS00060

(Wang et al., 2021)

is ameliorated by Dref^JF02232

(Wang et al., 2021)

is ameliorated by RPA1^GL00350

(Wang et al., 2021)

is ameliorated by SMC5^HMC04343

(Wang et al., 2021)

is ameliorated by fzr^GD9960

(Wang et al., 2021)

is ameliorated by mei-41^GL00284

(Wang et al., 2021)

is ameliorated by mre11^HMC02995

(Wang et al., 2021)

is exacerbated by stg^UAS.Tag:HA

(Wang et al., 2021)

is ameliorated by stg^RNAi.UAS.cUa

(Wang et al., 2021)

exacerbates cancer

modeled by Src64B^UAS.cCa

(Enomoto et al., 2021)

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

exacerbates carcinoma

modeled by scrib¹

(Brumby and Richardson, 2003)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell migration | larval stage, with Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

abnormal cell shape | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PP

(Ku and Sun, 2017)

abnormal neuroanatomy | embryonic stage 11, with Scer\GAL4^da.G32

(Arefin et al., 2019)

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^elav.PU

(Singh et al., 2025)

abnormal neuroanatomy | somatic clone, with Scer\GAL4^Act5C.PI

(Wang et al., 2006)

abnormal neuroanatomy | somatic clone | third instar larval stage

(Toriya et al., 2006)

abnormal size | adult stage, with Scer\GAL4^ey.PS

(Fre et al., 2009)

abnormal size | third instar larval stage, with Scer\GAL4^ey.PS

(Fre et al., 2009)

decreased cell number | embryonic stage 11, with Scer\GAL4^da.G32

(Arefin et al., 2019)

decreased cell number | somatic clone | third instar larval stage

(Toriya et al., 2006)

decreased occurrence of cell division | embryonic stage 16, with Scer\GAL4^wor.PA

(Sood et al., 2022)

decreased rate of adult locomotory behavior, with Scer\GAL4^ey.PU

(Singh et al., 2025)

hyperplasia, with Scer\GAL4^ey.PU

(Bayraktar et al., 2006)

hyperplasia | cell non-autonomous | somatic clone, with Scer\GAL4^Act5C.PI

(Chao et al., 2004)

hyperplasia | larval stage, with Scer\GAL4^ey.PU

(Surabhi et al., 2015)

hyperplasia | pharate adult stage | somatic clone, with Scer\GAL4^Act5C.PP

(Reynolds-Kenneally and Mlodzik, 2005)

hyperplasia | somatic clone, with Scer\GAL4^Act5C.PP

(Reynolds-Kenneally and Mlodzik, 2005)

increased cell death | somatic clone | wandering third instar larval stage, with Scer\GAL4^Act5C.PI

(Moon et al., 2005)

increased cell number | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Reynolds-Kenneally and Mlodzik, 2005)

increased cell number | third instar larval stage, with Scer\GAL4^{E(spl)m6-BFM.PF}

(Aradhya et al., 2015)

increased cell number | wandering third instar larval stage, with Scer\GAL4^ct-PG142

(Pitsouli and Perrimon, 2013)

increased occurrence of cell division | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Reynolds-Kenneally and Mlodzik, 2005)

increased occurrence of cell division | third instar larval stage, with Scer\GAL4^ey.PS

(Fre et al., 2009)

increased size | adult stage, with Scer\GAL4^ey.PU

(Singh et al., 2025)

lethal, with Scer\GAL4^ey.PH

(Kurata et al., 2000)

lethal - all die during embryonic stage, with Scer\GAL4^ptc.PU

(Singh et al., 2025)

neoplasia | larval stage, with Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

neoplasia | third instar larval stage, with Scer\GAL4^ap.PU

(Sachan et al., 2013)

neoplasia | third instar larval stage, with Scer\GAL4^ey.PU

(Sachan et al., 2013)

partially lethal - majority live, with Scer\GAL4^ey.PU

(Sachan et al., 2013)

short lived, with Scer\GAL4^ey.PU

(Sachan et al., 2013)

visible, with Scer\GAL4^T113

(Go et al., 1998)

visible | adult stage, with Scer\GAL4^bbg-C96

(Singh et al., 2025)

visible | adult stage, with Scer\GAL4^ey.PS

(Fre et al., 2009)

visible | adult stage, with Scer\GAL4^ey.PU

(Singh et al., 2025, Sachan et al., 2013)

Phenotype Manifest In

abdominal dorsal adult muscle precursor cell | third instar larval stage, with Scer\GAL4^{E(spl)m6-BFM.PF}

(Aradhya et al., 2015)

abdominal lateral adult muscle precursor cell | third instar larval stage, with Scer\GAL4^{E(spl)m6-BFM.PF}

(Aradhya et al., 2015)

adult head | somatic clone, with Scer\GAL4^Act5C.PP

(Reynolds-Kenneally and Mlodzik, 2005)

C1 chordotonal organ precursor cell, with Scer\GAL4^en-e16E

(Brodu et al., 2004)

egg chamber | somatic clone, with Scer\GAL4^Act5C.PI

(Wilkin et al., 2024)

embryonic/larval crystal cell | ectopic, with Scer\GAL4^hs.PB

(Lebestky et al., 2003)

embryonic/larval dorsal tracheal branch, with Scer\GAL4^btl.PS

(Ghabrial and Krasnow, 2006)

embryonic/larval lymph gland, with Scer\GAL4^hs.PB

(Lebestky et al., 2003)

embryonic/larval lymph gland, with Scer\GAL4^Mef2.PR

(Mandal et al., 2004)

embryonic/larval oenocyte precursor, with Scer\GAL4^en-e16E

(Brodu et al., 2004)

embryonic/larval tracheal section, with Scer\GAL4^btl.PS

(Steneberg et al., 1999)

embryonic/larval tracheal section, with Scer\GAL4^esg-p127

(Steneberg et al., 1999)

embryonic central brain | embryonic stage 16, with Scer\GAL4^wor.PA

(Sood et al., 2022)

embryonic hindgut, with Scer\GAL4^byn-Gal4

(Takashima et al., 2002)

embryonic large intestine, with Scer\GAL4^byn-Gal4

(Takashima et al., 2002)

embryonic neuroblast | embryonic stage 11, with Scer\GAL4^da.G32

(Arefin et al., 2019)

embryonic neuroblast | embryonic stage 16, with Scer\GAL4^wor.PA

(Sood et al., 2022)

embryonic ventral nerve cord, with Scer\GAL4^elav.PU

(Singh et al., 2025)

eye, with Scer\GAL4^ey.PH

(Kurata et al., 2000)

eye, with Scer\GAL4^ey.PS

(Fre et al., 2009)

eye, with Scer\GAL4^ey.PU

(Singh et al., 2025)

eye, with Scer\GAL4^T113

(Go et al., 1998)

eye | ectopic, with Scer\GAL4^ey.PH

(Kurata et al., 2000)

eye-antennal disc | somatic clone, with Scer\GAL4^Act5C.PP

(Reynolds-Kenneally and Mlodzik, 2005)

eye-antennal disc | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PP

(Ku and Sun, 2017)

eye disc, with Scer\GAL4^dpp.blk1

(Chern and Choi, 2002)

eye disc, with Scer\GAL4^ey.PU

(Bayraktar et al., 2006)

eye disc | larval stage, with Scer\GAL4^ey.PU

(Singh et al., 2025, Surabhi et al., 2015)

eye disc | somatic clone, with Scer\GAL4^Act5C.PI

(Chao et al., 2004)

eye disc | third instar larval stage, with Scer\GAL4^ey.PS

(Fre et al., 2009)

eye disc | third instar larval stage, with Scer\GAL4^ey.PU

(Sachan et al., 2013)

eye disc anterior to the morphogenetic furrow | cell non-autonomous | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Reynolds-Kenneally and Mlodzik, 2005)

eye disc morphogenetic furrow | third instar larval stage, with Scer\GAL4^ey.PS

(Fre et al., 2009)

eye disc posterior to the morphogenetic furrow | cell autonomous | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Reynolds-Kenneally and Mlodzik, 2005)

eye photoreceptor cell, with Scer\GAL4^ey.PH

(Lee et al., 2009)

eye photoreceptor precursor cell | larval stage, with Scer\GAL4^ey.PU

(Singh et al., 2025)

female germline cyst | somatic clone, with Scer\GAL4^Act5C.PI

(Wilkin et al., 2024)

follicle stem cell | somatic clone, with Scer\GAL4^Act5C.PI

(Wilkin et al., 2024)

interommatidial bristle | adult stage, with Scer\GAL4^ey.PU

(Sachan et al., 2013)

larval neuroblast | somatic clone, with Scer\GAL4^Act5C.PI

(Akiba et al., 2024)

larval neuroblast | somatic clone | third instar larval stage

(Toriya et al., 2006)

leg disc, with Scer\GAL4^T113

(Go et al., 1998)

medulla anlage | larval stage | somatic clone, with Scer\GAL4^Act5C.PI

(Akiba et al., 2024)

myoblast | P-stage, with Scer\GAL4¹¹⁵¹

(Dutta et al., 2004)

neuroblast | supernumerary & larval brain | somatic clone, with Scer\GAL4^Act5C.PI

(Wang et al., 2006)

neuron | somatic clone | third instar larval stage

(Toriya et al., 2006)

oenocyte primordium, with Scer\GAL4^en-e16E

(Brodu et al., 2004)

ommatidium, with Scer\GAL4^ey.PH

(Kurata et al., 2000)

ommatidium | adult stage, with Scer\GAL4^ey.PU

(Sachan et al., 2013)

ommatidium | ectopic, with Scer\GAL4^ey.PH

(Kurata et al., 2000)

photoreceptor neuron | ectopic, with Scer\GAL4^ey.PH

(Kurata et al., 2000)

sensory mother cell | ectopic, with Scer\GAL4^ptc-559.1

(Matsuno et al., 2002)

stalk follicle cell | somatic clone, with Scer\GAL4^Act5C.PI

(Wilkin et al., 2024)

tracheolar cell | wandering third instar larval stage, with Scer\GAL4^ct-PG142

(Pitsouli and Perrimon, 2013)

wing, with Scer\GAL4^bbg-C96

(Singh et al., 2025)

wing disc, with Scer\GAL4^30A

(Go et al., 1998)

wing disc, with Scer\GAL4^71B

(Go et al., 1998)

wing disc, with Scer\GAL4^A9

(Go et al., 1998)

wing disc, with Scer\GAL4^ap-md544

(Nfonsam et al., 2012)

wing disc, with Scer\GAL4^c766

(Go et al., 1998)

wing disc, with Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018, Go et al., 1998)

wing disc, with Scer\GAL4^T113

(Go et al., 1998)

wing disc, with Scer\GAL4^vg.int2.1

(Go et al., 1998)

wing disc | somatic clone | wandering third instar larval stage, with Scer\GAL4^Act5C.PI

(Moon et al., 2005)

wing disc | third instar larval stage, with Scer\GAL4^ap.PU

(Sachan et al., 2013)

Detailed Description

Statement

Reference

The expression of N^ICN.UAS under the control of Scer\GAL4^wor.PA results in fewer central brain neuroblasts proliferating (i.e. increased numbers in S-phase) in stage 16 embryos, as compared to controls.

(Sood et al., 2022)

At stage 11 expression of N^ICN.UAS under the control of Scer\GAL4^da.G32 leads to a reduction in neuroblast numbers when compared to control embryos.

(Arefin et al., 2019)

Expressing N^ICN.UAS under the control of Scer\GAL4^dpp.blk1 leads to misshapen wing discs; sone cells originating from the wing disc's Dpp-positive domain show an invasive phenotype.

(Blaquiere et al., 2018)

Third instar larval eye-antennal disc clones expressing N^ICN.UAS under the control of Scer\GAL4^Act5C.PP exhibit ectopic epithelial folding when located in a normally non-folding region. The cells at the ectopic fold show apical constriction and reduced apical and basolateral volumes, as compared to controls, and appear more similar to cells at the A1 fold.

(Ku and Sun, 2017)

The expression of N^ICN.Scer\UAS under the control of Scer\GAL4^{E(spl)m6-BFM.PF} leads to significantly increased numbers of abdominal lateral and dorsal, but not ventral, adult muscle precursor cells in mid-third instar larvae, as compared to controls; this expression does not affect the number of mitotic adult muscle precursor cells at embryonic stages, as compared to controls.

(Aradhya et al., 2015)

Ectopic expression of N^ICN.UAS under the control of Scer\GAL4^ct-PG142 (in combination with a Gal80[ts] transgene to overcome embryonic and larval lethality) in spiracular branch growth zone 3 leads to an excessive proliferation.

(Pitsouli and Perrimon, 2013)

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4^ey.PU results in rough eye phenotype with irregular and fused ommatidia and extra or missing interommatidial bristles in the adult eye and leads to eye (Scer\GAL4^ey.PU driver) or wing (Scer\GAL4^ap.PU driver) disc overgrowth in third instar larvae.

(Sachan et al., 2013)

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4^ap-md544 results in an increase in size of the wing disc.

(Nfonsam et al., 2012)

Expression of N^ICN.Scer\UAS driven by Scer\GAL4^ey.PS results in an enlarged adult eye, and increased cell proliferation, associated with enlargement of the morphogenetic furrow, in third instar larva eye discs, which do not show any obvious differentiation defects.

(Fre et al., 2009)

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4^ey.PH results in a loss of photoreceptors in the eye disc.

(Lee et al., 2009)

The overall number and positioning of the longitudinal glia in the embryo is not altered by expression of N^ICN.Scer\UAS under the control of Scer\GAL4^htl.POS.

(Thomas and van Meyel, 2007)

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4^ey.PU results in hyperplasia of the eye disc.

(Bayraktar et al., 2006)

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4^btl.PS arrests outgrowth of the dorsal tracheal branch and results in the stalling of cells near the base. Some dorsal branches completely fail to bud in the posterior metameres.

(Ghabrial and Krasnow, 2006)

Expression of N^ICN.Scer\UAS in eye discs using the Scer\GAL4^GMR.PF driver greatly reduces the number of elav-positive cells, indicating a strong inhibition of photoreceptor recruitment.

(Hagedorn et al., 2006)

Third instar clones expressing N^ICN.Scer\UAS have a similar number of cells in the larval outer optic anlage compared to control clones but have a reduced number of neurons in clones derived from post-embryonic neuroblasts (inhibits neuronal differentiation).

(Toriya et al., 2006)

Expression of N^ICN.Scer\UAS in clones under the control of Scer\GAL4^Act5C.PI leads to the overproliferation of larval neuroblasts.

(Wang et al., 2006)

Expression of N^ICN.Scer\UAS in all the prohemocytes using the Scer\GAL4^srp.D.cCa driver does not generate more crystal cells. Expression of N^ICN.Scer\UAS in all the plasmatocytes using the Scer\GAL4^svr-PG33 driver does not generate more crystal cells.

(Bataille et al., 2005)

Cells in regions of the late third instar wing disc which are normally insensitive to irradiation induced apoptosis become sensitive to it if they are part of N^ICN.Scer\UAS; Scer\GAL4^Act5C.PI somatic clones. (40Gy of γ rays; assayed after 4hrs)

(Moon et al., 2005)

Cells within Scer\GAL4^Act5C.PP > N^ICN.Scer\UAS Flip-out somatic clones generated along the furrow and posterior to the furrow of the eye-antennal disc, using Scer\FLP1^hs.PG, incorporate BrdU cell-autonomously. More cells within the clone enter S-phase than surrounding wild-type cells. Clones of the same genotype generated anterior to the furrow are non-autonomous, as both cells within the clone and cells surrounding the clone incorporate increased levels of BrdU and enter S-phase at an increased rate. Flip-out Scer\GAL4^Act5C.PP > N^ICN.Scer\UAS somatic clones generated in the eye-antennal discs, using Scer\FLP1^ey.PN, have a growth advantage over wild-type tissue, thus covering most of the eye tissue. Such discs are severly hyperplasic and lose much of their normal morphology. Cells across the disc appear to be proliferating in an asynchronous manner, instead of such proliferation being restricted to the region of the disc anterior to the furrow. There is no significant cellular differentiation within such discs. However, the antennal and eye primordia are correctly patterned. Resulting pharate adults have overgrown tissue within the head, with no discernable features or structure, exept for a few residual pigment cells.

(Reynolds-Kenneally and Mlodzik, 2005)

N^ICN.Scer\UAS; Scer\GAL4^en-e16E embryos lack C1 chordotonal organ precursor cells and have no larval oenocyte precursors.

(Brodu et al., 2004)

N^ICN.Scer\UAS; Scer\GAL4^Act5C.PI clones in the eye disc can induce overgrowth when located anterior to the morphogenetic furrow. Clones near the lateral margin cause non-autonomous overgrowth, whereas centrally located clones cause only local overgrowth.

(Chao et al., 2004)

N^ICN.Scer\UAS; Scer\GAL4¹¹⁵¹ pupae lack dorsal-ventral indirect flight muscle founder myoblasts.

(Dutta et al., 2004)

Overexpression of N^ICN.Scer\UAS, under the control of Scer\GAL4^Mef2.PR, causes a marked increase in lymph-gland size in late-stage-15 embryos.

(Mandal et al., 2004)

When N^ICN.Scer\UAS is driven by Scer\GAL4^hs.PB a dramatic increase is seen in the number of crystal cell precursors in the lymph gland. They are also seen in the second lobe, where they are rarely seen in wild-type.

(Lebestky et al., 2003)

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4^dpp.blk1 results in gross overgrowth of the eye disc in both dorsal and ventral domains.

(Chern and Choi, 2002)

When N^ICN.Scer\UAS is driven by Scer\GAL4^ptc-559.1 a row of ectopic sensory organ precursors (SOPs) are induced in the wing disc.

(Matsuno et al., 2002)

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4^byn-Gal4 in the embryo results in the entire large intestine differentiating into boundary cells. The large intestine becomes short and thick in these animals.

(Takashima et al., 2002)

Expression of N^ICN.Scer\UAS driven by Scer\GAL4^ey.PH leads to pupal lethality. Those few that do escape lethality show hyperplasia of the eyes, with a significant increase in the number of facets. At larval stages the eye dics are overgrown. About 16% of escapers formed ectopic eyes on the rostral membrane of the head.

(Kurata et al., 2000)

When expression is driven by Scer\GAL4^btl.PS the branching pattern of the embryonic trachea is normal but the metameres remain unconnected at the end of embryogenesis. Fusion cell fate has been abolished. When expression is driven by Scer\GAL4^p127 63% of the dorsal branches do not fuse and 48% of the branches do not express the hdc fusion cell marker.

(Steneberg et al., 1999)

Flies expressing N^ICN.Scer\UAS under the control of Scer\GAL4^T113 have slightly enlarged eyes. Largely suppresses the wing defects seen in flies expressing H^Scer\UAS.cGa under the control of Scer\GAL4^vg.int2.1. Larvae expressing N^ICN.Scer\UAS under the control of Scer\GAL4^vg.int2.1 have enlarged wing discs compared to wild-type. This phenotype is associated with elevated mitotic activity in the disc. Elevated mitotic activity is also seen in the wing disc when N^ICN.Scer\UAS is expressed under the control of Scer\GAL4^dpp.blk1, Scer\GAL4^71B, Scer\GAL4^30A or Scer\GAL4^c766. The dorsal side of the wing pouch is enlarged in larvae expressing N^ICN.Scer\UAS under the control of Scer\GAL4^A9. Larvae expressing N^ICN.Scer\UAS under the control of Scer\GAL4^T113 have enlarged wing discs compared to wild-type, and the leg discs appear abnormal.

(Go et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

N^ICN.UAS, Scer\GAL4^ey.PU has visible | adult stage phenotype, enhanceable by Kap-α3^UAS.Tag:HA, Scer\GAL4^ey.PU

(Sachan et al., 2013)

N^ICN.UAS, Scer\GAL4^ey.PU has neoplasia | third instar larval stage phenotype, enhanceable by Kap-α3^UAS.Tag:HA, Scer\GAL4^ey.PU

(Sachan et al., 2013)

N^ICN.UAS, Scer\GAL4^ap.PU has neoplasia | third instar larval stage phenotype, enhanceable by Kap-α3^UAS.Tag:HA, Scer\GAL4^ap.PU

(Sachan et al., 2013)

N^ICN.UAS, Scer\GAL4^ey.PS has visible | adult stage phenotype, enhanceable by wg^d08266, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has abnormal size | adult stage phenotype, enhanceable by wg^d08266, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has abnormal size | third instar larval stage phenotype, enhanceable by wg^d08266, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has visible | adult stage phenotype, enhanceable by arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has abnormal size | adult stage phenotype, enhanceable by arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has abnormal size | third instar larval stage phenotype, enhanceable by arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has visible | adult stage phenotype, enhanceable by Apc^c00746

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has abnormal size | adult stage phenotype, enhanceable by Apc^c00746

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has abnormal size | third instar larval stage phenotype, enhanceable by Apc^c00746

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PU has hyperplasia phenotype, enhanceable by par-1^UAS.cBa, Scer\GAL4^ey.PU

(Bayraktar et al., 2006)

Suppressed by

Statement

Reference

N^ICN.UAS, Scer\GAL4^elav.PU has abnormal neuroanatomy | embryonic stage phenotype, suppressible by Awh^UAS.cUa, Scer\GAL4^elav.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU has decreased rate of adult locomotory behavior phenotype, suppressible | partially by Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^bbg-C96 has visible | adult stage phenotype, suppressible by Awh^UAS.cUa, Scer\GAL4^bbg-C96

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU has visible | adult stage phenotype, suppressible by Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU has hyperplasia | larval stage phenotype, suppressible by mahe^UAS.Tag:HA, Scer\GAL4^ey.PU

(Surabhi et al., 2015)

N^ICN.UAS, Scer\GAL4^ey.PU has short lived phenotype, suppressible by Kap-α3^UAS.Tag:HA, Scer\GAL4^ey.PU

(Sachan et al., 2013)

N^ICN.UAS has decreased cell number | somatic clone | third instar larval stage phenotype, suppressible by Hsap\NUMB^{UAS.PTBS-PRRS}

(Toriya et al., 2006)

NOT suppressed by

Statement

Reference

N^ICN.UAS has decreased cell number | somatic clone | third instar larval stage phenotype, non-suppressible by Hsap\NUMB^{UAS.PTBS-PRRL}

(Toriya et al., 2006)

Enhancer of

Statement

Reference

N^ICN.UAS, Scer\GAL4^dpp.blk1 is an enhancer of neoplasia | larval stage phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

NOT Enhancer of

Statement

Reference

N^ICN.UAS, Scer\GAL4^dpp.blk1 is a non-enhancer of abnormal cell migration | larval stage phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

Suppressor of

Statement

Reference

N^ICN.UAS, Scer\GAL4^ey.PU is a suppressor of decreased cell number | larval stage phenotype of Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU is a suppressor of visible | adult stage phenotype of Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU is a suppressor of decreased size | adult stage phenotype of Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU is a suppressor | partially of decreased rate of adult locomotory behavior phenotype of Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^vg.PU is a suppressor of increased cell death | larval stage phenotype of Awh^UAS.cUa, Scer\GAL4^vg.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^NP7397 is a suppressor of abnormal cell number | adult stage phenotype of CG12744^RNAi.UAS.cUa, Scer\GAL4^NP7397

(Liu and Jin, 2017)

N^ICN.UAS, Scer\GAL4^bbg-C96 is a suppressor of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

N^ICN.UAS, Scer\GAL4^bbg-C96 is a suppressor of visible phenotype of Rbf^280.UAS, Scer\GAL4^bbg-C96

(Kwon et al., 2013)

N^ICN.UAS, Scer\GAL80^ts.αTub84B, Scer\GAL4^bab1-Gal4 is a suppressor of decreased cell number phenotype of InR^E19/InR³³⁹

(Yang et al., 2013)

N^ICN.UAS/Scer\GAL4^arm.PS is a suppressor | partially of neurogenic phenotype | maternal effect | embryonic stage phenotype of pcx³

(Yamakawa et al., 2012)

N^ICN.UAS/Scer\GAL4¹¹⁵¹ is a suppressor of abnormal planar polarity phenotype of chas¹

(Olguín et al., 2011)

Scer\GAL4^Act5C.PU/N^ICN.UAS is a suppressor | partially of abnormal cell polarity | recessive | somatic clone phenotype of flw^FP41

(Sun et al., 2011)

N^ICN.UAS, Scer\GAL4^vg.int2.1 is a suppressor of visible phenotype of H^UAS.cGa, Scer\GAL4^vg.int2.1

(Go et al., 1998)

NOT Suppressor of

Statement

Reference

N^ICN.UAS, Scer\GAL4^dpp.blk1 is a non-suppressor of abnormal cell migration | larval stage phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

N^ICN.UAS/Scer\GAL4^Act5C.PI is a non-suppressor of abnormal size | somatic clone | adult stage phenotype of GATAe¹

(Okumura et al., 2016)

Other

Statement

Reference

Awh^UAS.cUa, N^ICN.UAS, Scer\GAL4^bbg-C96 has visible | adult stage phenotype

(Singh et al., 2025)

Awh^UAS.cUa, N^ICN.UAS, Scer\GAL4^bbg-C96 has decreased size | adult stage phenotype

(Singh et al., 2025)

Myc^KK103869, N^ICN.UAS, Scer\GAL4^{E(spl)m6-BFM.PF} has decreased cell number | third instar larval stage phenotype

(Aradhya et al., 2015)

Hsap\NUMB^{UAS.PTBS-PRRL}, N^ICN.UAS has increased cell number | somatic clone | third instar larval stage phenotype

(Toriya et al., 2006)

N^ICN.UAS, Scer\GAL4^ey.PH, eyg^M3-12 has partially lethal - majority die phenotype

(Chao et al., 2004)

N^ICN.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has lethal | somatic clone | pupal stage phenotype

(Brumby and Richardson, 2003)

N^ICN.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia phenotype

(Brumby and Richardson, 2003)

N^ICN.UAS, Scer\GAL4^αTub84B.PL, scrib¹ has neoplasia | somatic clone | larval stage phenotype

(Brumby and Richardson, 2003)

Antp^UAS.cBa, N^ICN.UAS, Scer\GAL4^ey.PH has lethal phenotype

(Kurata et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

N^ICN.UAS, Scer\GAL4^ap.PU has wing disc | third instar larval stage phenotype, enhanceable by Kap-α3^UAS.Tag:HA, Scer\GAL4^ap.PU

(Sachan et al., 2013)

N^ICN.UAS, Scer\GAL4^ey.PU has ommatidium | adult stage phenotype, enhanceable by Kap-α3^UAS.Tag:HA, Scer\GAL4^ey.PU

(Sachan et al., 2013)

N^ICN.UAS, Scer\GAL4^ey.PU has interommatidial bristle | adult stage phenotype, enhanceable by Kap-α3^UAS.Tag:HA, Scer\GAL4^ey.PU

(Sachan et al., 2013)

N^ICN.UAS, Scer\GAL4^ey.PU has eye disc | third instar larval stage phenotype, enhanceable by Kap-α3^UAS.Tag:HA, Scer\GAL4^ey.PU

(Sachan et al., 2013)

N^ICN.UAS, Scer\GAL4^ey.PS has eye phenotype, enhanceable by wg^d08266, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has eye disc | third instar larval stage phenotype, enhanceable by wg^d08266, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has eye disc morphogenetic furrow | third instar larval stage phenotype, enhanceable by wg^d08266, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has eye phenotype, enhanceable by arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has eye disc | third instar larval stage phenotype, enhanceable by arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has eye disc morphogenetic furrow | third instar larval stage phenotype, enhanceable by arm^{S10.UAS.Tag:MYC}, Scer\GAL4^ey.PS

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has eye phenotype, enhanceable by Apc^c00746

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has eye disc | third instar larval stage phenotype, enhanceable by Apc^c00746

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PS has eye disc morphogenetic furrow | third instar larval stage phenotype, enhanceable by Apc^c00746

(Fre et al., 2009)

N^ICN.UAS, Scer\GAL4^ey.PU has eye disc phenotype, enhanceable by par-1^UAS.cBa, Scer\GAL4^ey.PU

(Bayraktar et al., 2006)

Suppressed by

Statement

Reference

N^ICN.UAS, Scer\GAL4^elav.PU has embryonic ventral nerve cord phenotype, suppressible by Awh^UAS.cUa, Scer\GAL4^elav.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^bbg-C96 has wing phenotype, suppressible by Awh^UAS.cUa, Scer\GAL4^bbg-C96

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU has eye phenotype, suppressible by Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU has eye disc | larval stage phenotype, suppressible by Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU has eye photoreceptor precursor cell | larval stage phenotype, suppressible by Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU has eye disc | larval stage phenotype, suppressible by mahe^UAS.Tag:HA, Scer\GAL4^ey.PU

(Surabhi et al., 2015)

N^ICN.UAS, Scer\GAL4^ey.PH has eye photoreceptor cell phenotype, suppressible by Hipk³/Hipk³

(Lee et al., 2009)

N^ICN.UAS has neuron | somatic clone | third instar larval stage phenotype, suppressible by Hsap\NUMB^{UAS.PTBS-PRRS}

(Toriya et al., 2006)

N^ICN.UAS, Scer\GAL4^en-e16E has oenocyte primordium phenotype, suppressible by rho^UAS.cdCa

(Brodu et al., 2004)

N^ICN.UAS, Scer\GAL4^en-e16E has embryonic/larval oenocyte precursor phenotype, suppressible by rho^UAS.cdCa

(Brodu et al., 2004)

N^ICN.UAS, Scer\GAL4^dpp.blk1 has eye disc phenotype, suppressible by L^si

(Chern and Choi, 2002)

NOT suppressed by

Statement

Reference

N^ICN.UAS has neuron | somatic clone | third instar larval stage phenotype, non-suppressible by Hsap\NUMB^{UAS.PTBS-PRRL}

(Toriya et al., 2006)

N^ICN.UAS, Scer\GAL4^en-e16E has C1 chordotonal organ precursor cell phenotype, non-suppressible by rho^UAS.cdCa

(Brodu et al., 2004)

N^ICN.UAS, Scer\GAL4^ptc-559.1 has sensory mother cell | ectopic phenotype, non-suppressible by dx^ΔPRM.UAS, Scer\GAL4^ptc-559.1

(Matsuno et al., 2002)

Enhancer of

Statement

Reference

N^ICN.UAS, Scer\GAL4^dpp.blk1 is an enhancer of wing disc phenotype of Hipk^UAS.Tag:HA, Scer\GAL4^dpp.blk1

(Blaquiere et al., 2018)

N^ICN.UAS, Scer\GAL4^ap-md544 is an enhancer of wing disc phenotype of Scer\GAL4^ap-md544, ey^UAS.cHa

(Nfonsam et al., 2012)

N^ICN.UAS, Scer\GAL4^ap-md544 is an enhancer of ommatidium | ectopic phenotype of Scer\GAL4^ap-md544, ey^UAS.cHa

(Nfonsam et al., 2012)

Suppressor of

Statement

Reference

N^ICN.UAS, Scer\GAL4^ey.PU is a suppressor of eye photoreceptor precursor cell | larval stage | decreased number phenotype of Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU is a suppressor of eye phenotype of Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^ey.PU is a suppressor of eye disc | larval stage phenotype of Awh^UAS.cUa, Scer\GAL4^ey.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^vg.PU is a suppressor of wing disc phenotype of Awh^UAS.cUa, Scer\GAL4^vg.PU

(Singh et al., 2025)

N^ICN.UAS, Scer\GAL4^NP7397 is a suppressor of adult gut phenotype of CG12744^RNAi.UAS.cUa, Scer\GAL4^NP7397

(Liu and Jin, 2017)

N^ICN.UAS, Scer\GAL4^bbg-C96 is a suppressor of wing margin phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

N^ICN.UAS, Scer\GAL4^bbg-C96 is a suppressor of wing margin phenotype of Rbf^280.UAS, Scer\GAL4^bbg-C96

(Kwon et al., 2013)

N^ICN.UAS, Scer\GAL80^ts.αTub84B, Scer\GAL4^bab1-Gal4 is a suppressor of female germline stem cell phenotype of InR^E19/InR³³⁹

(Yang et al., 2013)

N^ICN.UAS, Scer\GAL80^ts.αTub84B, Scer\GAL4^bab1-Gal4 is a suppressor of germarium cap cell phenotype of InR^E19/InR³³⁹

(Yang et al., 2013)

N^ICN.UAS/Scer\GAL4^arm.PS is a suppressor of endoplasmic reticulum | maternal effect phenotype of pcx³

(Yamakawa et al., 2012)

N^ICN.UAS/Scer\GAL4¹¹⁵¹ is a suppressor of chaeta phenotype of chas¹

(Olguín et al., 2011)

Scer\GAL4^Act5C.PU/N^ICN.UAS is a suppressor | partially of oocyte | somatic clone phenotype of flw^FP41

(Sun et al., 2011)

N^ICN.UAS/Scer\GAL4^dpp.blk1 is a suppressor | partially of eye phenotype of eyg¹/eyg^M3-12

(Chao et al., 2004)

N^ICN.UAS/Scer\GAL4^ey.PH is a suppressor of head phenotype of eyg^M3-12

(Chao et al., 2004)

N^ICN.UAS, Scer\GAL4^vg.int2.1 is a suppressor of wing phenotype of H^UAS.cGa, Scer\GAL4^vg.int2.1

(Go et al., 1998)

NOT Suppressor of

Statement

Reference

N^ICN.UAS/Scer\GAL4^Act5C.PI is a non-suppressor of adult posterior midgut epithelium | somatic clone phenotype of GATAe¹

(Okumura et al., 2016)

N^ICN.UAS is a non-suppressor of embryonic/larval oenocyte precursor | increased number phenotype of Scer\GAL4^en-e16E, rho^UAS.cdCa

(Brodu et al., 2004)

N^ICN.UAS is a non-suppressor of embryonic/larval oenocyte | increased number phenotype of Scer\GAL4^en-e16E, rho^UAS.cdCa

(Brodu et al., 2004)

N^ICN.UAS is a non-suppressor of oenocyte primordium phenotype of Scer\GAL4^en-e16E, rho^UAS.cdCa

(Brodu et al., 2004)

Other

Statement

Reference

Awh^UAS.cUa, N^ICN.UAS, Scer\GAL4^bbg-C96 has wing phenotype

(Singh et al., 2025)

Myc^KK103869, N^ICN.UAS, Scer\GAL4^{E(spl)m6-BFM.PF} has abdominal lateral adult muscle precursor cell | third instar larval stage phenotype

(Aradhya et al., 2015)

Myc^KK103869, N^ICN.UAS, Scer\GAL4^{E(spl)m6-BFM.PF} has abdominal dorsal adult muscle precursor cell | third instar larval stage phenotype

(Aradhya et al., 2015)

Myc^KK103869, N^ICN.UAS, Scer\GAL4^{E(spl)m6-BFM.PF} has abdominal ventral adult muscle precursor cell | third instar larval stage phenotype

(Aradhya et al., 2015)

Kap-α3^D93, N^ICN.UAS, Scer\GAL4^Tub.PU has larval brain | somatic clone | third instar larval stage phenotype

(Sachan et al., 2013)

N^ICN.UAS, Scer\GAL4^ey.PH, eyg^M3-12 has eye disc phenotype

(Chao et al., 2004)

N^ICN.UAS, Scer\GAL4^ey.PH, eyg^M3-12 has antennal disc | increased number phenotype

(Chao et al., 2004)

N^ICN.UAS, Scer\GAL4^ey.PH, eyg^M3-12 has eye disc | ectopic phenotype

(Chao et al., 2004)

Antp^UAS.cBa, N^ICN.UAS, Scer\GAL4^ey.PH has leg | ectopic phenotype

(Kurata et al., 2000)

N^ICN.UAS, Scer\GAL4^ey.PH, ey² has eye | ectopic phenotype

(Kurata et al., 2000)

N^ICN.UAS, Scer\GAL4^ey.PH, ey² has antenna | ectopic phenotype

(Kurata et al., 2000)

N^ICN.UAS, Scer\GAL4^ey.PH, ey^R has eye | ectopic phenotype

(Kurata et al., 2000)

Antp^UAS.cBa, N^ICN.UAS, Scer\GAL4^ey.PH has leg phenotype

(Kurata et al., 2000)

Antp^UAS.cBa, N^ICN.UAS, Scer\GAL4^ey.PH has head phenotype

(Kurata et al., 2000)

Antp^UAS.cBa, N^ICN.UAS, Scer\GAL4^ey.PH has wing | ectopic phenotype

(Kurata et al., 2000)

N^ICN.UAS, Scer\GAL4^T113, vg^UAS.cKa has imaginal disc phenotype

(Go et al., 1998)

N^ICN.UAS, Scer\GAL4^dpp.blk1, vg^UAS.cKa has imaginal disc phenotype

(Go et al., 1998)

N^ICN.UAS, Scer\GAL4^T113, vg^UAS.cKa has eye disc phenotype

(Go et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The small size of GATAe¹ homozygote MARCM clone in adult posterior midgut is not rescued by expression of N^ICN.Scer\UAS under the control of Scer\GAL4^Act5C.PI.

(Okumura et al., 2016)

The co-expression of Myc^KK103869 and N^ICN.Scer\UAS under the control of Scer\GAL4^{E(spl)m6-BFM.PF} leads to significantly decreased numbers of abdominal lateral, dorsal and ventral adult muscle precursor cells in third instar larvae, as compared to controls.

(Aradhya et al., 2015)

Expression of mahe^{Scer\UAS.T:Ivir\HA1} partially suppresses the highly proliferated eye tissue phenotype seen when N^ICN.Scer\UAS is expressed under the control of Scer\GAL4^ey.PU.

(Surabhi et al., 2015)

The wing nicking phenotype caused by expression of Rbf^280.Scer\UAS under the control of Scer\GAL4^bbg-C96 is suppressed if the flies are also co-expressing N^ICN.Scer\UAS.

The wing nicking phenotype caused by expression of dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96 is suppressed if the flies are also co-expressing N^ICN.Scer\UAS.

(Kwon et al., 2013)

The nuclear translocation of Notch-ICD (intracellular part of the N receptor) in somatic MARCM clones expressing N^ICN.Scer\UAS under the control of Scer\GAL4^tub.PU in third instar larval brain is blocked when the clones are also homozygous mutant for Kap-α3^D93.

The adult eye defects - irregularities in size and spacing of ommatidia and aberrant numbers of interommatidial bristles - as well as decreased eclosion rate and reduced adult life-span observed in flies expressing N^ICN.Scer\UAS under the control of Scer\GAL4^ey.PU is exacerbated further by co-expression of Kap-α3^{Scer\UAS.T:Ivir\HA1}. The neoplastic overgrowth of both eye and wing discs induced by N^ICN.Scer\UAS expression (controlled by either the Scer\GAL4^ey.PU or the Scer\GAL4^ap.PU driver, respectively) is also strongly enhanced by Kap-α3^{Scer\UAS.T:Ivir\HA1} co-expression.

(Sachan et al., 2013)

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4^bab1-Gal4 (limited to the adult stages using Scer\GAL80^ts.αTub84B) significantly suppresses the germline stem cell and cap cell loss seen in InR³³⁹/InR^E19 mutant week old females.

(Yang et al., 2013)

Co-expression of N^ICN.Scer\UAS results in enlarged wing discs containing a larger field (30-40% of disc surface area) of differentiating ectopic eye precursors compared to expression of ey^Scer\UAS.cHa alone under the control of Scer\GAL4^ap-md544.

(Nfonsam et al., 2012)

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4^arm.PS in pcx³ embryos which lack maternal and zygotic pcx function partially rescues the neurogenic phenotype: 44% of embryos are rescued, 48% are partially rescued and 8% are not rescued. The endoplasmic reticulum defects are also rescued.

(Yamakawa et al., 2012)

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4¹¹⁵¹ suppresses the planar polarity defects seen in the notum of chas¹ flies.

(Olguín et al., 2011)

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4^Act5C.PU partially suppresses the oocyte polarity defect seen when the posterior follicle cells are mutant for flw^FP41.

(Sun et al., 2011)

The co-expression of pan^ΔN.Scer\UAS suppresses the enlarged eye in adults and the increased proliferation and enlarged morphogenetic furrow in third instar larva eye discs expressing N^ICN.Scer\UAS driven by Scer\GAL4^ey.PS.

Apc^c00746 or the co-expression of either wg^d08266 or arm^{S10.Scer\UAS.T:Hsap\MYC} enhance the eye defects in adults expressing N^ICN.Scer\UAS driven by Scer\GAL4^ey.PS, with associated wrinkling and distortion in third instar larva eye discs, but no obvious differentiation defects are visible in these discs.

(Fre et al., 2009)

hipk³/hipk³ suppresses the loss of photoreceptors in the eye disc caused by expression of N^ICN.Scer\UAS under the control of Scer\GAL4^ey.PH.

(Lee et al., 2009)

Expression of N^ICN.Scer\UAS and par-1^Scer\UAS.cBa under the control of Scer\GAL4^ey.PU results in profound hyperplasia of the eye disc.

(Bayraktar et al., 2006)

Homozygous mutant aux^I670K eye discs that also express N^ICN.Scer\UAS (under the control of Scer\GAL4^GMR.PF) exhibit a reduction in the number of elav-positive cells, indicating that N is epistatic to aux.

(Hagedorn et al., 2006)

The absence of oenocyte formation in N^ICN.Scer\UAS; Scer\GAL4^en-e16E embryos is rescued by rho^{Scer\UAS.cdCa}. The absence of chordotonal organ precursor C1 formation is not.

(Brodu et al., 2004)

N^ICN.Scer\UAS; Scer\GAL4^dpp.blk1 partially restores eye development in eyg¹/eyg^M3-12 flies.

(Chao et al., 2004)

When N^ICN.Scer\UAS are expressed in scrib¹ clones, massive overproliferation of the scrib¹ tissue is seen inducing larval/pupal lethality.

(Brumby and Richardson, 2003)

L^si strongly suppresses the overgrowth of the ventral part of the eye disc in animals expressing N^ICN.Scer\UAS under the control of Scer\GAL4^dpp.blk1, but has little effect on dorsal outgrowth of the eye discs in these animals.

(Chern and Choi, 2002)

The addition of dx^{ΔPRM.Scer\UAS} does not suppress the ectopic SOP phenotype seen in N^ICN.Scer\UAS, Scer\GAL4^ptc-559.1 animals.

(Matsuno et al., 2002)

Expression of Antp^Scer\UAS.cBa and N^ICN.Scer\UAS driven by Scer\GAL4^ey.PH is lethal. About 1/4 of those few escapers that do survive are found to have ectopic wings on their heads that usually consisted of dorsal and ventral wing blades bordered by bristles of the wing margin, but lacking wing veins. About 17% of these flies showed ectopic leg structures induced by secondary transformation of the ectopic antennal tissue into leg structures, an additional 10% showed a transformation of the original antenna to leg structures.

(Kurata et al., 2000)

Larvae expressing both N^ICN.Scer\UAS and vg^Scer\UAS.cKa under the control of Scer\GAL4^T113 show striking overgrowth of the eye discs. Other imaginal discs also show overgrowth. This overgrowth phenotype is also seen if the Scer\GAL4^dpp.blk1 driver is used instead of Scer\GAL4^T113.

(Go et al., 1998)

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\NUMB^{Scer\UAS.PTBS-PRRS} partially suppresses the inhibition of neuronal differentiation seen in clones with expression of N^ICN.Scer\UAS in third instar larval neuroblasts.

Co-expression of Hsap\NUMB^{Scer\UAS.PTBS-PRRL} increases the number of neuroepithelial cells but does not suppress the inhibition of neuronal differentiation seen in clones with expression of N^ICN.Scer\UAS in third instar larval neuroblasts.

(Toriya et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Carried in plasmid " pUAST:NotchICD " and transfected into S3 cells.

(Klueg et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

N^ACT

(Ghabrial and Krasnow, 2006, Brumby and Richardson, 2003)

N^ICN.Scer\UAS

N^ICN.UAS

N^ICN

(Vachias et al., 2010)

N^intra

(Olguín et al., 2011)

Notch^ΔECD

(Sood et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (90)

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