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General Information
Symbol
Dmel\Src64BUAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Cooper
FlyBase ID
FBal0097107
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Src64
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Wild-type Src64B is expressed under the control of UAS regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing Src64BUAS.cCa under the control of Scer\GAL4GMR.PF leads to massive defects in eye development when flies are raised at 25[o]C, but only mild defects at 18[o]C. At 18[o]C a significant proportion of CadN-immunopositive adherens junctions between photoreceptor precursor cells R3 and R4 in row 5 ommatidia of wandering third instar larvae are shorter compared to controls.

Scer\GAL4esg-NP5130-mediated expression of Src64BScer\UAS.cCa (restricted to adult stages by using P{tubP-GAL80ts}) results in substantial intestinal stem cell hyperproliferation and hyperplasia of the adult intestine.

When expression is driven by Scer\GAL47B, Src64BScer\UAS.cCa shows a mushroom body Class III phenotype; axonal growth and guidance defects. The beta lobes are abortive and the alpha lobes enlarged. Phenotype is similar though more dramatic - all axons stop at the peduncle - when Src64BScer\UAS.cCa is driven by Scer\GAL4OK107.

Expression of Src64BScer\UAS.cCa under the control of Scer\GAL4slbo.2.6 impairs border cell and centripetal cell migration.

ISNb bypass phenotypes are not produced when Src64BScer\UAS.cCa is expressed under the control of Scer\GAL4elav.PLu.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Src64BScer\UAS.cCa
Src64BUAS.cCa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Cooper
Secondary FlyBase IDs
    References (7)