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General Information
Symbol
Dmel\eyg1
Species
D. melanogaster
Name
FlyBase ID
FBal0003939
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

eyg1/Df(3L)eygC1 mutants have a small eye disc and show a complete loss of the retina.

eyg1/eygM3-12 flies have no eyes, whereas eyg1 homozygotes have small eyes.

eyg1 homozygotes, eyg1/In(3L)gvU and eyg1/eygM3-12 animals exhibit a small eye phenotype. Increased apoptosis can be seen anterior to the morphogenetic furrow in the developing eye-disc in homozygous mutant larvae.

The eye disc does not reach its normal size and shape in mutant flies and no photoreceptors differentiate. Photoreceptor development proceeds normally in most homozygous clones in the eye disc. eyg1/Df(3L)iro-2 hemizygous eye discs completely lack photoreceptors.

Homozygotes show reduced larval and pupal survival.

Eyes and head much smaller than normal. Considerable pupal mortality, probably from inability to push open pupa cases. Adults normal in viability and productivity. Character subject to genetic modifiers and possibly environmental influences. Expression varies from complete absence of facets to formation of about 100 facets. RK2.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

eyg1 has visible phenotype, enhanceable by Df(1)os1

Other
Statement
Reference

ey1, eyg1 has lethal phenotype

Phenotype Manifest In
Enhanced by
Statement
Reference

eyg1 has eye phenotype, enhanceable by upd11

eyg1 has eye phenotype, enhanceable by Df(1)os1

Suppressed by
NOT suppressed by
Statement
Reference

eyg1/eygM3-12 has eye phenotype, non-suppressible by Scer\GAL4ey.PH/BacA\p35UAS.cHa

Enhancer of
Statement
Reference

eyg1/eyg1 is an enhancer of eye phenotype of upd11

Other
Statement
Reference

eyg1, eym1 has eye phenotype

Additional Comments
Genetic Interactions
Statement
Reference

HE31/+ partially restores eye development in eyg1/eygM3-12 flies, as does NICN.Scer\UAS; Scer\GAL4dpp.blk1 or Su(H)Scer\UAS.cNa; Scer\GAL4dpp.blk1. upd1Scer\UAS.cZa; Scer\GAL4dpp.blk1 completely restores eye development in eyg1/eygM3-12 flies. Df(1)os1; eyg1 double homozygotes lack eyes.

The addition of eyScer\UAS.cHa driven by Scer\GAL4ey.PH can partially rescue the eygM3-12/eyg1 mutant eye phenotype.

Photoreceptor development in eyg1/Df(3L)iro-2 discs is not rescued by tkvQ253D.Scer\UAS.cNb, dppScer\UAS.cFa or hhScer\UAS.cAa expressed under the control of Scer\GAL4dpp.PH. Photoreceptor development in eyg1/Df(3L)iro-2 discs is rescued by sggS9A.Scer\UAS, panΔN.Scer\UAS or Ras85DV12.Scer\UAS expressed under the control of Scer\GAL4dpp.PH.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (10)