FB2026_02 , released June 18, 2026
Allele: Dmel\mei-41GL00284
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General Information
Symbol
Dmel\mei-41GL00284
Species
D. melanogaster
Name
FlyBase ID
FBal0262753
Feature type
allele
Associated gene
Dmel\mei-41
Associated Insertion(s)
Carried in Construct
P{TRiP.GL00284}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.GL00284}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-GL00284
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by NICN.UAS
      (Wang et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Females heterozygous for mei-41GL00284 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to mei-41GL00284 males results in: 20% hatching; egg/embryonic phenotype: "variable seg phenotype, U-shaped"; maternal effect.

      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      mei-41GL00284/Scer\GAL4nanos.PU is an enhancer of decreased cell number | adult stage | female | temperature conditional phenotype of Crei\I-CreIhs.PR

      (Ma et al., 2016)
      NOT Suppressor of
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      mei-41GL00284/Scer\GAL4nanos.PU is an enhancer of female germline stem cell | adult stage | temperature conditional phenotype of Crei\I-CreIhs.PR

      (Ma et al., 2016)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The loss of germline stem cells (GSCs) observed upon heat-shock induced expression of Crei\I-CreIhs.PR (to introduce DNA damage) is further exacerbated by expression of mei-41GL00284 under the Scer\GAL4nos.PU driver.

      (Ma et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mei-41GL00284
      Name Synonyms
      Secondary FlyBase IDs
        References (5)