FlyBase Allele Report: Dmel\chas[1]

General Information

Symbol

Dmel\chas¹

Species

D. melanogaster

Name

FlyBase ID

FBal0260706

Feature type

allele

Associated gene

Dmel\chas

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

FLPase

Nature of the Allele

Allele class

loss of function allele

(Olguín et al., 2011)

Mutagen

FLPase

(Olguín et al., 2011)

Progenitor genotype

P{XP}d02121

(Olguín et al., 2011)

PBac{RB}chas^e01663

(Olguín et al., 2011)

Cytology

Description

Recombination between the two progenitor insertions has deleted the sequence between them, removing part of the chas gene.

(Olguín et al., 2011)

Deletion that includes the 5' untranslated regions and start codons of both chas isoforms.

(Olguín et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:17,676,888..17,698,747 [-]

Comment:

Deletion that includes the 5' untranslated regions and 5' coding exons of all chas isoforms.

(Olguín et al., 2011)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Olguín et al., 2011)

abnormal planar polarity | cell non-autonomous | somatic clone

(Olguín et al., 2011)

fertile

(Olguín et al., 2011)

viable

(Olguín et al., 2011)

Phenotype Manifest In

mesonotum

(Olguín et al., 2011)

Detailed Description

Statement

Reference

Mutant flies have anterior indentations in the notum epidermis.

(Olguín et al., 2011)

Mutants show planar polarity defects in the notum.

Homozygous clones in the notum nonautonomously influence the polarity of neighbouring bristles and trichomes.

(Olguín et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

chas¹ has abnormal planar polarity phenotype, enhanceable by dpy^ov1

(Olguín et al., 2011)

chas¹ has visible phenotype, enhanceable by dpy^ov1

(Olguín et al., 2011)

chas¹ has abnormal planar polarity phenotype, enhanceable by jbug^BG00406/jbug[+]

(Olguín et al., 2011)

Suppressed by

Statement

Reference

chas¹ has abnormal planar polarity phenotype, suppressible by N^ICN.UAS/Scer\GAL4¹¹⁵¹

(Olguín et al., 2011)

Enhancer of

Statement

Reference

chas¹ is an enhancer of abnormal planar polarity phenotype of dpy^ov1

(Olguín et al., 2011)

chas¹ is an enhancer of visible phenotype of dpy^ov1

(Olguín et al., 2011)

Other

Statement

Reference

chas¹, fz²¹ has abnormal planar polarity phenotype

(Olguín et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

chas¹ has mesonotum phenotype, enhanceable by dpy^ov1

(Olguín et al., 2011)

Suppressed by

Statement

Reference

chas¹ has chaeta phenotype, suppressible by N^ICN.UAS/Scer\GAL4¹¹⁵¹

(Olguín et al., 2011)

Enhancer of

Statement

Reference

chas¹ is an enhancer of mesonotum phenotype of dpy^ov1

(Olguín et al., 2011)

Other

Statement

Reference

chas¹, fz²¹ has chaeta phenotype

(Olguín et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

chas¹ dp^ov1 double mutants show enhanced indentations of the anterior notum epidermis and enhanced planar polarity defects compared to either single mutant.

jbug^BG00406/+ enhances the planar polarity defects seen in the notum of chas¹ mutants.

(Olguín et al., 2011)

chas¹ ; fz²¹ double mutants show a novel phenotype, with bristles on the notum oriented towards the anterior.

Expression of N^ICN.Scer\UAS under the control of Scer\GAL4¹¹⁵¹ suppresses the planar polarity defects seen in the notum of chas¹ flies.

(Olguín et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

chas¹

(Olguín et al., 2011, Olguín et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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