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General Information
Symbol
Dmel\CycEHMS00060
Species
D. melanogaster
Name
FlyBase ID
FBal0257095
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
HMS00060
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of CycEHMS00060 under the control of Scer\GAL4A58 leads to the larval epidermis presenting small nuclei, as compared to controls; there are no apparent defects in wound closure.

The expression of CycEHMS00060 under the control of Scer\GAL4moody.PU results in a compromised blood-brain barrier in the adult, as dye injected into the body cavity is able to diffuse into the brain. Only at higher expression conditions (i.e. at 25[o]C but not at 18[o]C), larvae show the same blood-brain barrier defects, their brains are significantly smaller and their subperineurial glial cells present septate junction discontinuity (Dlg immunostaining), as well as significant decreases in nuclear size or ploidy.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
CycEHMS00060
Name Synonyms
Secondary FlyBase IDs
    References (4)