FlyBase Allele Report: Dmel\EMC3[GD1074]

General Information

Symbol

Dmel\EMC3^GD1074

Species

D. melanogaster

Name

FlyBase ID

FBal0205197

Feature type

allele

Associated gene

Dmel\EMC3

Associated Insertion(s)

Carried in Construct

P{GD1074}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1074}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1074

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of intestinal cancer

CEA

(Shi et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of intestinal cancer

is ameliorated by Rpn1^HMS01337

(Shi et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult enteroendocrine cell | decreased number, with Scer\GAL4^{Delta-05151-G}

(Shi et al., 2023)

adult enteroendocrine cell | increased number, with Scer\GAL4^esg.PU

(Shi et al., 2023)

adult midgut, with Scer\GAL4^{Delta-05151-G}

(Shi et al., 2023)

adult midgut, with Scer\GAL4^esg.PU

(Shi et al., 2023)

adult midgut, with Scer\GAL4^NP0001

(Shi et al., 2023)

adult midgut | somatic clone, with Scer\GAL4^unspecified

(Shi et al., 2023)

enteroblast | adult stage | increased number, with Scer\GAL4^esg.PU

(Shi et al., 2023)

Detailed Description

Statement

Reference

Adults expressing EMC3^GD1074 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1074

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

EMC3^GD1074, Scer\GAL4^esg.PU has increased cell number | adult stage phenotype, suppressible by yki^HMS00041, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has increased occurrence of cell division | adult stage phenotype, suppressible by hpo^{T195E.UAS.Tag:FLAG}, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^unspecified has increased size | somatic clone phenotype, suppressible by yki^B5/yki^B5

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has increased cell number | adult stage phenotype, suppressible | partially by Myc^JF01761, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has increased cell number | adult stage phenotype, suppressible | partially by CycE^HMS00060, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has increased cell number | adult stage phenotype, suppressible | partially by Diap1^HMS00752, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has increased cell number | adult stage phenotype, suppressible by Rpn1^HMS01337, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has increased cell number | adult stage phenotype, suppressible by hpo^{UAS.WT.Tag:FLAG}, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has increased occurrence of cell division | adult stage phenotype, suppressible by hpo^{UAS.WT.Tag:FLAG}, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has increased cell number | adult stage phenotype, suppressible by hpo^{T195E.UAS.Tag:FLAG}, Scer\GAL4^esg.PU

(Shi et al., 2023)

NOT suppressed by

Statement

Reference

EMC3^GD1074, Scer\GAL4^esg.PU has increased cell number | adult stage phenotype, non-suppressible by hpo^{T195A.UAS.Tag:FLAG}, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has increased occurrence of cell division | adult stage phenotype, non-suppressible by hpo^{T195A.UAS.Tag:FLAG}, Scer\GAL4^esg.PU

(Shi et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

EMC3^GD1074, Scer\GAL4^esg.PU has adult midgut phenotype, suppressible | partially by Myc^JF01761, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has adult midgut phenotype, suppressible | partially by CycE^HMS00060, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has adult midgut phenotype, suppressible | partially by Diap1^HMS00752, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has adult midgut phenotype, suppressible by Rpn1^HMS01337, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has adult midgut phenotype, suppressible by hpo^{UAS.WT.Tag:FLAG}, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has adult midgut phenotype, suppressible by hpo^{T195E.UAS.Tag:FLAG}, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^esg.PU has adult midgut phenotype, suppressible by yki^HMS00041, Scer\GAL4^esg.PU

(Shi et al., 2023)

EMC3^GD1074, Scer\GAL4^unspecified has adult midgut | somatic clone phenotype, suppressible by yki^B5/yki^B5

(Shi et al., 2023)

NOT suppressed by

Statement

Reference

EMC3^GD1074, Scer\GAL4^esg.PU has adult midgut phenotype, non-suppressible by hpo^{T195A.UAS.Tag:FLAG}, Scer\GAL4^esg.PU

(Shi et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

EMC3^GD1074 is rescued by EMC3^UAS.Tag:MYC/Scer\GAL4^esg.PU

(Shi et al., 2023)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v9408

w¹¹¹⁸ P{GD1074}v9408

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1074

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG6750^GD1074

EMC3^GD1074

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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