FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hpoUAS.WT.Tag:FLAG
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General Information
Symbol
Dmel\hpoUAS.WT.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0279491
Feature type
allele
Associated gene
Dmel\hpo
Associated Insertion(s)
Carried in Construct
P{UAS-hpo.WT.FLAG}
Also Known As
UAS-Flag-Hpo
Key Links
Transgenic product class
wild_type
(Jin et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Jin et al., 2012)
Mutagen
in vitro construct
(Jin et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-hpo.WT.FLAG}
Cytology
Description

UAS regulatory sequences drive expression of wild-type hpo which is tagged with Tag:FLAG.

(Jin et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
hpo
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of hpoScer\UAS.WT.T:Zzzz\FLAG in adult flies under the control of Scer\GAL4esg-NP5130 results in impaired intestinal stem cell proliferation.

      (Jin et al., 2013)

      Expression of hpoScer\UAS.WT.T:Zzzz\FLAG under the control of Scer\GAL4Bx-MS1096 results in a strong reduction in wing size.

      (Jin et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of brmD718A.Scer\UAS.T:Zzzz\FLAG completely rescues the reduced intestinal stem cell proliferation seen when hpoScer\UAS.WT.T:Zzzz\FLAG is expressed in adult flies under the control of Scer\GAL4esg-NP5130, resulting in a dramatic increase in intestinal stem cells and enterocytes as well as mitotic cells.

      Expression of brmScer\UAS.T:Zzzz\FLAG only slightly suppresses the reduced intestinal stem cell proliferation seen when hpoScer\UAS.WT.T:Zzzz\FLAG is expressed under the control of Scer\GAL4esg-NP5130.

      (Jin et al., 2013)

      Co-expression of hpoScer\UAS.WT.T:Zzzz\FLAG and ykiScer\UAS.cZa under the control of Scer\GAL4GMR.PU results in small, rough eyes.

      (Jin et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      hpoUAS.WT.Tag:FLAG/Scer\GAL4Tub.PU rescues hpoBF33

      (Jin et al., 2012)
      Comments

      Expression of hpoScer\UAS.WT.T:Zzzz\FLAG under the control of Scer\GAL4tub.PU almost completely rescues the overgrowth phenotype caused by hpoBF33 clones in the eye.

      (Jin et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hpoScer\UAS.WT.T:Zzzz\FLAG
      hpoUAS.WT.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (4)