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General Information
Symbol
Dmel\HUAS.cGa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Go
FlyBase ID
FBal0090635
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-H, UAS-Hairless
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The entire H open reading frame is expressed under the control of UASt regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of HScer\UAS.cGa under the control of Scer\GAL4ey.PH results in complete loss of the eye.

Expression of HScer\UAS.cGa throughout the wing disc, under the control of Scer\GAL4sd-SG29.1, results in wing discs with no clear dorsal/ventral boundary.

Expression of HScer\UAS.cGa in non-sensory organ precursors, driven by Scer\GAL4mα.hs, converts some of these cells into sensory organ precursors that are either normal or display a double shaft phenotype.

Expression of HScer\UAS.cGa under the control of Scer\GAL4sca-537.4 results in a bristle socket-to-shaft transformation phenotype. The converted socket cells and normal shaft cells produce shafts of nearly equal length. All bristles lack normal sockets and have ectopic shaft structures in flies expressing HScer\UAS.cGa under the control of Scer\GAL4Su(H).ASE5.

Embryos expressing HScer\UAS.cGa under the control of Scer\GAL4byn-Gal4 lack hindgut boundary cells.

Expression of HScer\UAS.cGa under the control of Scer\GAL4byn-Gal4 in embryos strongly suppresses boundary cell differentiation in the hindgut.

Pupae in which HScer\UAS.cGa is expressed under the control of Scer\GAL4hs.PB using heat shock at 37oC for 2 hours during the tormogen-trichogen cell fate decision show socket-to-shaft cell fate transformations.

Larvae expressing HScer\UAS.cGa under the control of Scer\GAL4T113 have much smaller eye discs than normal. Adults derived from these larvae have small eyes, and in the most severe cases the eyes are missing. This eye phenotype is not associated with severe eye roughness. The flies also have small wings and halteres, and many extra thoracic bristles. Flies expressing HScer\UAS.cGa under the control of Scer\GAL4vg.int2.1 have wing defects ranging from wing margin notches to rudimentary wings.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Enhancer of
Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of hipkScer\UAS.T:Ivir\HA1 partially suppresses the complete eye loss caused by expression of HScer\UAS.cGa under the control of Scer\GAL4ey.PH; a small eye is seen.

Co-expression of groEE.cLa.Scer\UAS partially suppresses the complete eye loss caused by expression of HScer\UAS.cGa under the control of Scer\GAL4ey.PH; a small eye is seen.

Co-expression of groAA.cLa.Scer\UAS enhances the phenotype caused by expression of HScer\UAS.cGa under the control of Scer\GAL4ey.PH; the eye fails to develop, and head defects are increased, with the entire head being lost in 29% of flies and only the dorsal vertex of the head being present in 41% of the flies.

Co-expression of eyScer\UAS.cHa enhances the loss of eye phenotype caused by expression of HScer\UAS.cGa under the control of Scer\GAL4ey.PH.

Co-expression of eygScer\UAS.cUa suppresses the complete eye loss caused by expression of HScer\UAS.cGa under the control of Scer\GAL4ey.PH.

Eye development in HScer\UAS.cGa; Scer\GAL4ey.PH flies is partially rescued by eygScer\UAS.lune.

Enhances the wing nicking phenotype seen in mamN.Scer\UAS, Scer\GAL4C96 flies.

Strong synergistic effects are seen in flies expressing HScer\UAS.cGa under the control of Scer\GAL4T113 and also carrying SerBd-3. The wing defects of flies expressing HScer\UAS.cGa under the control of Scer\GAL4vg.int2.1 are largely suppressed if they are also carrying NICN.Scer\UAS.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Su(H)Scer\UAS.cGa under the control of Scer\GAL4tin.CΔ4 fails to rescue the abnormal cardiac function of Df(2L)Exel7007 flies.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
HScer\UAS.cGa
HUAS.cGa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Go
Secondary FlyBase IDs
    References (15)