FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sik2UAS.Tag:MYC
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General Information
Symbol
Dmel\Sik2UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0258122
Feature type
allele
Associated gene
Dmel\Sik2
Associated Insertion(s)
Carried in Construct
P{UAS-SIK2.Myc}
Key Links
Transgenic product class
wild_type
(Choi et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Choi et al., 2011)
Mutagen
in vitro construct
(Choi et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-SIK2.Myc}
Cytology
Description

UASt regulatory sequences drive expression of Sik2 coding sequences tagged with Tag:MYC.

(Choi et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Sik2
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  cancer
      modeled by HipkUAS.Tag:HA
      (Yu et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of SIK2Scer\UAS.T:Hsap\MYC in the developing eye under the control of Scer\GAL4GMR.PF does not generate any apparent phenotype.

      (Choi et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of SIK2Scer\UAS.T:Hsap\MYC with TORCScer\UAS.T:Zzzz\FLAG in the developing eye, both under the control of Scer\GAL4GMR.PF, restores ommatidial structure and eye size.

      Co-expression of SIK2Scer\UAS.T:Hsap\MYC with TORCS157D.Scer\UAS.T:Zzzz\FLAG in the developing eye, both under the control of Scer\GAL4GMR.PF fails to rescue the defective ommatidia and mechanosensory bristles seen upon expression of TORCS157D.Scer\UAS.T:Zzzz\FLAG alone.

      (Choi et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/Sik2UAS.Tag:MYC rescues Sik2Δ41

      (Choi et al., 2011)
      Fails to rescue

      Scer\GAL4Cg.PA/Sik2UAS.Tag:MYC fails to rescue Sik2Δ41

      (Choi et al., 2011)
      Comments

      Neuronal expression of SIK2Scer\UAS.T:Hsap\MYC (under the control of Scer\GAL4elav-C155) in a SIK2Δ41 background reduces the glycogen and lipid content levels to those seen in controls in both fed and starved conditions.

      Fat-body expression of SIK2Scer\UAS.T:Hsap\MYC (under the control of Scer\GAL4Cg.PA) in a SIK2Δ41 background does not alter either the glycogen or lipid content levels.

      A dramatic decrease in starvation resistance to the level found in wild-type controls is observed in SIK2Δ41 mutants after expression of exogenous SIK2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155 but not Scer\GAL4Cg.PA.

      (Choi et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SIK2Scer\UAS.T:Hsap\MYC
      Sik2Scer\UAS.T:Hsap\MYC
      Sik2UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)