FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sik2Δ41
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General Information
Symbol
Dmel\Sik2Δ41
Species
D. melanogaster
Name
FlyBase ID
FBal0258121
Feature type
allele
Associated gene
Dmel\Sik2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Choi et al., 2011)
Progenitor genotype
Sik2G366
(Choi et al., 2011)
Cytology
Description

Imprecise excision of P{EP}SIK2G366 results in a 1,148bp deletion within the SIK2 gene, including the translation start site and the ATP-binding site of the kinase domain.

(Choi et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:2,059,929..2,061,079 [-]
Comment:

A 1,148bp deletion resulting from the imprecise excision of P{EP}Sik2G366 reported to map to X:1953962..1955112 in Release 5 coordinates.

(Choi et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      One-week old SIK2Δ41 mutants exhibit higher amounts of lipid and stored glycogen when compared with controls. This difference becomes more apparent after 24 hours of starvation. These flies do not exhibit a difference to controls in body weight or food intake.

      Under starvation conditions, the median and maximum survival times increased by 26 and 20% respectively, in SIK2Δ41 flies when compared to controls.

      (Choi et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Sik2Δ41 has long lived | calorie restriction conditional phenotype, suppressible by Crtc25-3

      (Choi et al., 2011)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A TORC25-3 heterozygous background decreases the lipid and glycogen levels in a fed and starved SIK2Δ41 mutant. A TORC25-3 homozygous background further decreases the lipid and glycogen levels in a fed and starved SIK2Δ41 mutant. As the level of TORC decreases, the flies become more sensitive to starvation.

      Expression of TORCS157D.Scer\UAS.T:Zzzz\FLAG (under the control of Scer\GAL4hs.PB) in fed and starved SIK2Δ41 mutants reduces the lipid and glycogen levels.

      As CrebB-17A levels are decreased (through expression of CrebB-17AKK108927 under the control of Scer\GAL4elav-C155) the increased lipid stores and starvation resistance of SIK2Δ41 flies are strongly inhibited.

      (Choi et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Sik2Δ41 is rescued by Scer\GAL4elav-C155/Sik2UAS.Tag:MYC

      (Choi et al., 2011)
      Not rescued by

      Sik2Δ41 is not rescued by Scer\GAL4Cg.PA/Sik2UAS.Tag:MYC

      (Choi et al., 2011)
      Comments

      Neuronal expression of SIK2Scer\UAS.T:Hsap\MYC (under the control of Scer\GAL4elav-C155) in a SIK2Δ41 background reduces the glycogen and lipid content levels to those seen in controls in both fed and starved conditions.

      Fat-body expression of SIK2Scer\UAS.T:Hsap\MYC (under the control of Scer\GAL4Cg.PA) in a SIK2Δ41 background does not alter either the glycogen or lipid content levels.

      A dramatic decrease in starvation resistance to the level found in wild-type controls is observed in SIK2Δ41 mutants after expression of exogenous SIK2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155 but not Scer\GAL4Cg.PA.

      (Choi et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SIK2Δ41
      SIKΔ41
      (Choi et al., 2011)
      Sik2Δ41
      (Şahin et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)