FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CrtcS157D.UAS.Tag:FLAG
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General Information
Symbol
Dmel\CrtcS157D.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0258120
Feature type
allele
Associated gene
Dmel\Crtc
Associated Insertion(s)
Carried in Construct
P{UAS-TORC-FLAG.S157D}
Key Links
Transgenic product class
missense_variant
(Choi et al., 2011)
polypeptide_post_translational_processing_variant
(Choi et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Choi et al., 2011)
polypeptide_post_translational_processing_variant
(Choi et al., 2011)
Mutagen
in vitro construct
(Choi et al., 2011)
Progenitor genotype
CrtcUAS.Tag:FLAG
(Choi et al., 2011)
Carried in construct
P{UAS-TORC-FLAG.S157D}
Cytology
Description

Amino acid replacement: S157D.

(Choi et al., 2011)

UASt regulatory sequences drive expression of Crtc coding sequences carrying a mutation that removes a phosphorylation site.

(Choi et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Crtc
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of TORCS157D.Scer\UAS.T:Zzzz\FLAG in the developing eye under the control of Scer\GAL4GMR.PF results in a severe eye phenotype with loss of ommatidia and mechanosensory bristles.

      (Choi et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of SIK2Scer\UAS.T:Hsap\MYC with TORCS157D.Scer\UAS.T:Zzzz\FLAG in the developing eye, both under the control of Scer\GAL4GMR.PF fails to rescue the defective ommatidia and mechanosensory bristles seen upon expression of TORCS157D.Scer\UAS.T:Zzzz\FLAG alone.

      Expression of TORCS157D.Scer\UAS.T:Zzzz\FLAG (under the control of Scer\GAL4hs.PB) in fed and starved SIK2Δ41 mutants reduces the lipid and glycogen levels.

      (Choi et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CrtcS157D.Scer\UAS.T:Zzzz\FLAG
      CrtcS157D.UAS.Tag:FLAG
      TORCS157D.Scer\UAS.T:Zzzz\FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (1)