FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wgNE2
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General Information
Symbol
Dmel\wgNE2
Species
D. melanogaster
Name
FlyBase ID
FBal0094277
Feature type
allele
Associated gene
Dmel\wg
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Chao et al., 2007)
Mutagen
ethyl methanesulfonate
(Dierick and Bejsovec, 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: C242Y. Nucleotide substitution: G to A.

(Dierick and Bejsovec, 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:7,314,373..7,314,373 [+]
Nucleotide change:

G7314373A

Reported nucleotide change:

G?A

Amino acid change:

C242Y | wg-PA

Reported amino acid change:

C242Y

(Dierick and Bejsovec, 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      wgNE2 mutants exhibit a reduction in the zone of naked cuticle on the ventral side in between the denticle belts as well as a disruption of dorsal patterning, leading to a strong curvature of the embryonic cuticle.

      (Chao et al., 2007)

      Mutant embryos exhibit a strong loss of cluster II slou expressing muscle founder cells and a weak loss of cluster I slou expressing muscle founder cells.

      (Cox and Baylies, 2005)

      Homozygous embryos secrete patches of naked cuticle and denticle belts containing predominantly row 5 type denticles, with a low frequency of other denticle morphologies. Segmental pattern in the dorsal cuticle is abolished and the dorsal expanse is greatly reduced.

      (Dierick and Bejsovec, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      wgNE2 has ventral denticle belt phenotype, suppressible by SoxNNC14

      (Chao et al., 2007)

      wgNE2 has embryonic/first instar larval cuticle phenotype, suppressible | partially by SoxNNC14

      (Chao et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wgNE2 mutant ventral patterning phenotype is suppressed by SoxNNC14 to almost wild-type levels without rescuing dorsal patterning.

      (Chao et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      wg1

      (Dierick and Bejsovec, 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      wgNE2
      (Chao et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)