FlyBase Allele Report: Dmel\SoxN[NC14]

General Information

Symbol

Dmel\SoxN^NC14

Species

D. melanogaster

Name

FlyBase ID

FBal0194665

Feature type

allele

Associated gene

Dmel\SoxN

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q351?.

(Chao et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

MNV

2L:8,827,544..8,827,546 [+]

Comment:

Codon 351 is the site of an unspecified mutation in SoxN^NC14.

(Chao et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

SoxN^NC14/Df(2L)Exel7040 stage 11 mutants exhibit reduced neuroblast numbers when compared to control embryos.

(Arefin et al., 2019)

SoxN^NC14/Df(2L)Exel7040 transheterozygotes present significant decreases in the number of dividing neuroblasts and dividing neuroblast daughters during stages 13 and 14 of embryogenesis, as compared to controls; there is a significantly decreased neuroblast number at both embryonic stages, as compared to controls.

(Bahrampour et al., 2017)

SoxN^NC14 mutants exhibit embryonic lethality, with a pattern defect showing slightly greater expanses of naked cuticle than is observed in wild-type.

SoxN^NC14, in trans with Df(2L)Exel7040 exhibit no change from the homozygous mutant phenotype, indicating that SoxN^NC14 behaves as a null allele.

Homozygous SoxN^NC14 mutants derived from Df(3R)Espl22 exhibit increased naked cuticle.

(Chao et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

SoxN^NC14 has embryonic/first instar larval cuticle phenotype, enhanceable by pan[+]/pan²

(Chao et al., 2007)

SoxN^NC14 has ventral denticle belt phenotype, enhanceable by pan[+]/pan²

(Chao et al., 2007)

Enhancer of

Statement

Reference

SoxN^NC14 is an enhancer of embryonic/first instar larval cuticle phenotype of Scer\GAL4^e22c, pan^ΔN.UAS

(Chao et al., 2007)

SoxN^NC14 is an enhancer of ventral denticle belt phenotype of Scer\GAL4^e22c, pan^ΔN.UAS

(Chao et al., 2007)

Suppressor of

Statement

Reference

SoxN^NC14 is a suppressor of denticle phenotype of wg^l-17

(Bejsovec and Chao, 2012)

SoxN^NC14 is a suppressor of ventral denticle belt phenotype of wg^NE2

(Chao et al., 2007)

SoxN^NC14 is a suppressor | partially of embryonic/first instar larval cuticle phenotype of wg^NE2

(Chao et al., 2007)

SoxN^NC14 is a suppressor of embryonic/first instar larval cuticle phenotype of wg^l-17

(Chao et al., 2007)

SoxN^NC14 is a suppressor of ventral denticle belt phenotype of wg^l-17

(Chao et al., 2007)

Other

Statement

Reference

SoxN^NC14, ck^KT9, wg^l-17 has denticle phenotype

(Bejsovec and Chao, 2012)

Additional Comments

Genetic Interactions

Statement

Reference

SoxN^NC14 partially suppresses the wg^l-17 denticle phenotype: some segmentation is restored to the pattern, without increasing denticle diversity.

wg^l-17 ck^KT9 SoxN^NC14 triple mutant embryos show a dramatic reduction in denticle size and many of the denticles are fragmented into one or two short projections. Actin bundles in the epidermal cells are split into two or sometimes three separate aggregates.

(Bejsovec and Chao, 2012)

Approximately 55.2% of arm⁴/+ ; SoxN^NC14/+ double mutants appear phenotypically wild-type. Approximately 19.9% of mutants exhibit a 'lawn of denticles' phenotype, typical of arm mutants. The SoxN^NC14 mutation disrupts the dorsal pattern and reduces the size of the embryos. A SoxN-like phenotype is observed in approximately 17.5% of the double mutants. Approximately 7.4% of the double mutants exhibit a severe arm phenotype.

Approximately 56.7% of pan²/+ ; SoxN^NC14/+ double mutants appear phenotypically wild-type. Approximately 18.6% of mutants exhibit a 'lawn of denticles' phenotype, typical of arm mutants. The SoxN^NC14 mutation disrupts the dorsal pattern and reduces the size of the embryos. A SoxN-like phenotype is observed in approximately 18.9% of the double mutants. Approximately 5.8% of the double mutants exhibit a severe excess-naked-cuticle SoxN-like phenotype. The double mutants exhibit more extensive naked cuticle than SoxN^NC14 single mutants.

(Chao et al., 2007)

Xenogenetic Interactions

Statement

Reference

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^e22c in a heterozygous SoxN^NC14 results in a milder 'lawn of denticles' phenotype and also substantially rescues head cuticle defects and increases the overall size of the body compared to pan^ΔN.Scer\UAS x Scer\GAL4^e22c embryos.

(Chao et al., 2007)

Complementation and Rescue Data

Rescued by

SoxN^NC14 is rescued by SoxN^UAS.cOa

(Chao et al., 2007)

Comments

Expression of SoxN^Scer\UAS.cOa under the control of Scer\GAL4^arm.PS rescues the excessive naked-cuticle phenotype of SoxN^NC14 homozygotes. This treatment does not rescue embryonic lethality.

(Chao et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

91794

SoxN^NC14 P{neoFRT}40A/CyO

9938

dpy^ov1 SoxN^NC14 pr¹ cn¹/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

NC14

(Chao et al., 2007)

SoxN^NC14

(Reim, 2024.4.19, Clarembaux-Badell et al., 2022, Özel et al., 2022, Arefin et al., 2019, Bahrampour et al., 2019, Schilling et al., 2019, Bahrampour et al., 2017, Rizzo and Bejsovec, 2017, Bejsovec and Chao, 2012, Chao et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (10)

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