FB2026_02 , released June 18, 2026
Allele: Dmel\exMGH1
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General Information
Symbol
Dmel\exMGH1
Species
D. melanogaster
Name
FlyBase ID
FBal0246633
Feature type
allele
Associated gene
Dmel\ex
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Pellock et al., 2007)
Progenitor genotype
Cytology
Description

747 bp deletion in ex that shifts the reading frame after amino acid 1058, and results in truncation of the protein 49 amino acids after the frame shift.

(Pellock et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:446,082..446,828 [+]
Comment:

@ex[MGH1] is reported as a 747bp deletion that causes a frameshift after amino acid 1058 and truncates the protein 49aa after the frameshift. Due to ambiguity, the annotated location of the deletion may be shifted by 1 base in either direction relative to the actual location.

(Pellock et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the eye disc are larger than wild-type control clones and are round in shape.

      (Angus et al., 2012)

      exMGH1 mosaic clones in the eye display a strong over proliferation phenotype. Mosaic eyes are slightly rough, have irregular shapes, and contain ectopic bristles. Mosaic eyes contain significantly more ommatidia compared to control eyes. Mutant ommatidia frequently show defects in both ommatidial chirality and rotation. Non-autonomous ommatidial chirality and rotation defects are also observed in wild-type ommatidia located near clonal boundaries.

      The eye, wing and antennal imaginal discs from third instar exMGH1/exMGH2 mutant larvae are greatly overgrown compared to wild-type imaginal discs. Eye discs from exMGH1/exMGH2 transheterozygotes mutant discs have a greatly reduced number of differentiated photoreceptors.

      In exMGH1 mosaic mutant eyes where the majority of eye tissue is mutant, eye size is much smaller compared to control eyes.

      exMGH1 mutant clones show delayed cell cycle exit in the larval eye disc.

      exMGH1 mutant tissue in mature pupal retinas have only a slight increase in the number of interommatidial cells when compared to wild-type tissue. An irregular ommatidial lattice is observed, and many mutant ommatidia lack a regular hexagonal shape and have extra bristle cells.

      (Pellock et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      exMGH1 has interommatidial bristle | pupal stage phenotype, non-enhanceable by wg1

      (Pellock et al., 2007)
      Suppressed by
      Statement
      Reference

      exMGH1 has eye | somatic clone phenotype, suppressible | partially by wg1

      (Pellock et al., 2007)

      exMGH1 has eye disc | pupal stage phenotype, suppressible | partially by wg1

      (Pellock et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small eye phenotype of eyes composed almost entirely of exMGH1 mutant tissue is suppressed by the presence of wg1.

      The irregular ommatidial patterning of exMGH1 mutant pupal eye disc tissue is suppressed by wg1. No additional supernumerary interommatidial cells are observed.

      (Pellock et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Mmmm\willinScer\UAS.T:Avic\GFP under the control of Scer\GAL4tub.PU has no effect on the size or shape of exMGH1 clones in the eye disc.

      (Angus et al., 2012)

      Expression of BacA\p35GMR.PH in exMGH1 mutant eye tissue results in large numbers of supernumerary interommatidial bristles.

      (Pellock et al., 2007)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      exMGH1
      (Angus et al., 2012, Grusche et al., 2011, Pellock et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)