Duplication at the p53 locus. The 5' copy consists of wild-type exons 1 to 6, a partial insertion of pTV2 vector sequence, another copy of exon 6 and part of exon 7. The 3' copy lacks exon 1 and part of exon 2. A w+mW.hs marker and a single FRT site are located between the two copies.
The rough eye phenotype caused by expression of DrefScer\UAS.cSa under the control of Scer\GAL4GMR.PS is suppressed by p53-ns/+ and by p53-ns/p53-ns (with stronger suppression in the homozygous background).
The increase in the number of TUNEL-positive cells and the non-autonomous increase in BrdU incorporation seen in the wing discs in larvae expressing Rcom\RAcs2.Scer\UAS under the control of Scer\GAL4en-e16E at 30[o]C is largely suppressed by p53-ns.