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General Information
Symbol
Hsap\TP53R273C
Species
H. sapiens
Name
FlyBase ID
FBal0342178
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A BAC (CH322-115D03) containing a 20kb genomic fragment of the p53 locus in which exons 1-8 of p53 (coding for the predominant gene product) are replaced with a Hsap\TP53 cDNA (NM_000546.5) bearing a R273C mutation, which is a common hot-spot mutation in human cancer.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
This allele represents a human variant implicated in disease.
TP53:p.Arg273Cys
Variants Synonym(s)
TP53:p.Arg114Cys
TP53:p.Arg141Cys
TP53:p.Arg234Cys
Associated human disease model(s)
External database links
Comments concerning this variant
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference

Hsap\TP53R273C is a non-suppressor of decreased cell death | embryonic stage | conditional phenotype of p53-ns

Phenotype Manifest In
NOT Suppressor of
Statement
Reference

Hsap\TP53R273C is a non-suppressor of wing disc | embryonic stage | conditional phenotype of p53-ns

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Hsap\TP53R273C
Name Synonyms
Secondary FlyBase IDs
    References (2)