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General Information
Symbol
Dmel\sbb6
Species
D. melanogaster
Name
FlyBase ID
FBal0121536
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
mtv6
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{lacW} element resulting in a 4kb deletion. The protein produced consists of only 19 amino acids.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

sbbplt/sbb6 mutants exhibit a wing vein phenotype wherein wing vein L5 fails to reach the wing margin, and males of these mutants also fail to copulate.

Homozygous clones in the wing result in loss of wing margin.

24% of sbbEal17/sbb6 pharate adults have defective claws.

Homozygous clones in the leg results in a severe reduction in the size, particularly the width, of claws composed of mutant tissue. Homozygous clones in the antenna result in aristae which are reduced in length and fatter than normal and some sense organs on the third antennal segment are absent or lacking setae.

The ocellar triangle region is compressed in sbbEal17/sbb6 flies, resulting in fusion of ocelli, loss of interocellar bristles and loss and mispositioning of the ocellar bristles.

Homozygous clones result in almost complete loss of the ocellar triangle region, with a single ocellus often being the only structure remaining.

Homozygous clones result in defects in the wing margin; in the proximal anterior region, the large wide central bristles that normally develop in the triple row in this region are thinner than normal and in the posterior region, the bristles develop a socket and are longer than normal, indicating a partial transformation to the anterior fate.

Homozygous embryos derived from homozygous female germline clones have a segmental phenotype consisting of the deletion of three or more abdominal segments.

Homozygous clones in the wing result in abnormal phenotypes. Clones anterior to the second vein result in an ectopic vein anterior to the second vein and triple row bristles are transformed to double row bristles. A slight increase in the area posterior to vein L5 is seen and the vein pattern between L3 and L4 is disrupted.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

sbb[+]/sbb6 is an enhancer of visible | dominant phenotype of Bx1

sbb[+]/sbb6 is an enhancer of visible | dominant phenotype of hhMrt

Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

sbb[+]/sbb6 is an enhancer of wing margin phenotype of Bx1

sbb[+]/sbb6 is an enhancer of wing vein L3 phenotype of hhMrt

Other
Additional Comments
Genetic Interactions
Statement
Reference

Loss of one copy of sbb6 strongly enhances the hhMrt heterozygous adult wing phenotype. Wings show duplication of longitudinal wing vein L3 tissue, and enlargement of the anterior compartment. The sensory organs located in the most anterior wing margin (triple row bristles) are transformed into more posteriorly located bristles (double row bristles).

gro1/groE48 adults heterozygous for sbb6 show an enlarged anterior wing compartment. Ectopic longitudinal wing vein L2 and L3 tissue develops, and transformation of the anterior wing margin bristles into more posteriorly located sensory organs is observed.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (6)